476454-38-3

Upstream product

• 601-89-8 2-nitroresorcinol 
• 381710-01-6 5-bromo-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidineacetic acid ethyl ester 
• 3163-15-3 2-aminoresorcinol 

Downstream Products

• 476454-39-4 {4-[2-(2-benzyloxycarbonylamino-ethoxy)-6-hydroxy-phenylamino]-5-bromo-2-oxo-2H-pyrimidin-1-yl}-acetic acid ethyl ester 
• 482598-26-5 {4-[2-(3-benzyloxycarbonylamino-propoxy)-6-hydroxy-phenylamino]-5-bromo-2-oxo-2H-pyrimidin-1-yl}-acetic acid ethyl ester 
• 482598-29-8 [{[8-(3-benzyloxycarbonylamino-propoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid ethyl ester 
• 476454-44-1 [{[8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid ethyl ester 
• 482598-27-6 [8-(3-benzyloxycarbonylamino-propoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid ethyl ester 
• 482598-28-7 [8-(3-benzyloxycarbonylamino-propoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid 
• 476454-41-8 [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid ethyl ester 
• 476454-43-0 [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid 

Relevant academic research and scientific papers

Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes.

High-Affinity Peptide Nucleic Acid Oligomers Containing Tricyclic Cytosine Analogues

(Matrix Presented) Peptide nucleic acid (PNA) monomers containing the tricyclic cytosine analogues phenoxazine, 9-(2-aminoethoxy)phenoxazine (G-clamp), and 9-(3-aminopropoxy)phenoxazine (propyl-G-clamp) have been synthesized. The modified nucleobases were