476469-27-9

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 1877-71-0 benzene 1,3-dicarboxylic acid monomethyl ester 

Downstream Products

• 891200-81-0 3-(2-carboxyallyl)benzoic acid 
• 476469-31-5 3-(2-methoxycarbonylallyl)benzoic acid methyl ester 
• 22383-02-4 3-(m-Carboxyphenyl)-1,2-propandicarbonsaeure 
• 891201-31-3 3-(2-benzyloxycarbonylpent-4-enyl)benzoic acid benzyl ester 
• 891201-34-6 2-carboxy-2-(3-carboxybenzyl)succinic acid 
• 891201-30-2 3-(2-carboxy-pent-4-enyl)-benzoic acid 
• 891201-33-5 3-(5-ethoxycarbonylmethyl-2,2-dimethyl-4,6-dioxo[1,3]dioxan-5-ylmethyl)benzoic acid methyl ester 
• 891201-29-9 3-(5-allyl-2,2-dimethyl-4,6-dioxo[1,3]dioxan-5-ylmethyl)benzoic acid methyl ester 

Relevant academic research and scientific papers

Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach

Facile synthesis of α-substituted acrylate esters

Treatment of 5-monosubstituted Meldrum's acids with dimethylmethyleneimmonium iodide (Eschenmoser's iodide salt) in methanol gives α-substituted acrylate methyl esters in good yields. Easy access to 5-monosubstituted Meldrum's acids allowed us to synthesize a wide variety of α-substituted acrylate methyl esters. The reaction conditions are mild and tolerate many functional groups commonly used in organic synthesis; thus, this new method has potential as an alternative to conventional preparative methods for α-substituted acrylate esters.