476472-16-9Relevant articles and documents
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors
Gellibert, Fran?oise,Woolven, James,Fouchet, Marie-Hélène,Mathews, Neil,Goodland, Helen,Lovegrove, Victoria,Laroze, Alain,Nguyen, Van-Loc,Sautet, Stéphane,Wang, Ruolan,Janson, Cheryl,Smith, Ward,Krysa, Ga?l,Boullay, Valérie,De Gouville, Anne-Charlotte,Huet, Stéphane,Hartley, David
, p. 4494 - 4506 (2007/10/03)
Optimization of the screening hit 1 led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-β type I receptor, ALK5. Compounds 15 and 19, whic
