132308-19-1 Usage
Description
5-Chloropyridine-2-carboxylic acid methyl ester, also known as Methyl 5-Chloro-2-pyridinecarboxylate, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chlorinated pyridine ring and ester functional group, which contribute to its reactivity and utility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
5-Chloropyridine-2-carboxylic acid methyl ester is used as a reagent for the synthesis of (propyl)(trifluoromethyl)benzisoxazolyloxypropyl-substituted arylcarboxylic acids and heterarylcarboxylic acids. These compounds are designed to be potent and selective liver X receptor (LXR) agonists, which play a significant role in the regulation of cholesterol and lipid metabolism.
Application Reason:
The primary application of 5-Chloropyridine-2-carboxylic acid methyl ester in the pharmaceutical industry is to develop LXR agonists that can reverse cholesterol transport and increase high-density lipoprotein (HDL) levels in the body. This is particularly important for the treatment and management of various cardiovascular diseases, as HDL is known as the "good cholesterol" that helps remove low-density lipoprotein (LDL) or "bad cholesterol" from the bloodstream, reducing the risk of atherosclerosis and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 132308-19-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,3,0 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 132308-19:
(8*1)+(7*3)+(6*2)+(5*3)+(4*0)+(3*8)+(2*1)+(1*9)=91
91 % 10 = 1
So 132308-19-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3
132308-19-1Relevant articles and documents
PARG INHIBITORS AND METHOD OF USE THEREOF
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Paragraph 0601; 0602; 0603, (2020/02/16)
Provided herein are, inter alia, methods of treating cancer using compounds of the invention.
1-(DIHYDRONAPHTHALENYL)PYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS
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Page/Page column 47, (2013/12/03)
This invention relates to novel 1-(dihydronaphthalenyl)pyridones which are antagonists of the melanin-concentrating hormone receptor 1 (MCHR1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy
BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS
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Page/Page column 18, (2010/12/29)
The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1 ), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.
