476472-56-7 Usage
Uses
Used in Organic Synthesis:
2-(4-FLUOROPHENYL)-1-(6-METHYLPYRIDINE-2-YL)ETHANONE is used as a building block for the synthesis of more complex organic compounds. Its unique structural features, including the fluorophenyl and methylpyridine groups, enable the formation of diverse molecular architectures.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-FLUOROPHENYL)-1-(6-METHYLPYRIDINE-2-YL)ETHANONE is used as a starting material for the development of new drugs. The presence of a fluorine atom and a pyridine ring can significantly influence the compound's pharmacological properties, making it a valuable component in the design of novel therapeutic agents.
Used in Medicinal Chemistry:
2-(4-FLUOROPHENYL)-1-(6-METHYLPYRIDINE-2-YL)ETHANONE is employed as a key intermediate in the synthesis of bioactive molecules. Its structural features, such as the ketone group, allow for various chemical reactions, facilitating the creation of compounds with potential therapeutic applications.
Used in Nucleophilic Addition Reactions:
In chemical research, 2-(4-FLUOROPHENYL)-1-(6-METHYLPYRIDINE-2-YL)ETHANONE is utilized in nucleophilic addition reactions due to its ketone functionality. This reaction type allows for the introduction of new functional groups, expanding the compound's chemical and biological properties.
Used in Enolate Chemistry:
2-(4-FLUOROPHENYL)-1-(6-METHYLPYRIDINE-2-YL)ETHANONE is also used in enolate chemistry, where the ketone group can be deprotonated to form an enolate anion. This reactive intermediate can participate in various reactions, such as aldol condensation and Michael addition, leading to the formation of new carbon-carbon bonds and the synthesis of more complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 476472-56-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,6,4,7 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 476472-56:
(8*4)+(7*7)+(6*6)+(5*4)+(4*7)+(3*2)+(2*5)+(1*6)=187
187 % 10 = 7
So 476472-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H12FNO/c1-10-3-2-4-13(16-10)14(17)9-11-5-7-12(15)8-6-11/h2-8H,9H2,1H3
476472-56-7Relevant academic research and scientific papers
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
Sawyer, J. Scott,Beight, Douglas W.,Britt, Karen S.,Anderson, Bryan D.,Campbell, Robert M.,Goodson Jr., Theodore,Herron, David K.,Li, Hong-Yu,McMillen, William T.,Mort, Nicholas,Parsons, Stephen,Smith, Edward C. R.,Wagner, Jill R.,Yan, Lei,Zhang, Faming,Yingling, Jonathan M.
, p. 3581 - 3584 (2007/10/03)
We have expanded our previously reported series of pyrazole-based inhibitors of the TGF-β type I receptor kinase domain (TβR-I) to now include new 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole analogues. Limited examination of the SAR of this new series in both e
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
Sawyer, J. Scott,Anderson, Bryan D.,Beight, Douglas W.,Campbell, Robert M.,Jones, Michael L.,Herron, David K.,Lampe, John W.,McCowan, Jefferson R.,McMillen, William T.,Mort, Nicholas,Parsons, Stephen,Smith, Edward C. R.,Vieth, Michal,Weir, Leonard C.,Yan, Lei,Zhang, Faming,Yingling, Jonathan M.
, p. 3953 - 3956 (2007/10/03)
Pyrazole-based inhibitors of the transforming growth factor-β type I receptor kinase domain (TβR-I) are described. Examination of the SAR in both enzyme- and cell-based in vitro assays resulted in the emergence of two subseries featuring differing selectivity versus p38 MAP kinase. A common binding mode at the active site has been established by successful cocrystallization and X-ray analysis of potent inhibitors with the TβR-I receptor kinase domain.
