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7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]is a complex organic compound with a unique molecular structure that features a quinolinol backbone and a pyrrolo[1,2-b]pyrazol-3-yl side chain. 7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]is known for its ability to inhibit casein kinase 1δ, a protein kinase that plays a role in various cellular processes.
Used in Pharmaceutical Industry:
7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]is used as a casein kinase 1δ inhibitor for the treatment of neurodegenerative disorders. Its ability to inhibit this enzyme may help in managing the progression of diseases such as Alzheimer's, Parkinson's, and Huntington's, by modulating the underlying molecular pathways involved in these conditions.

476474-11-0

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476474-11-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 476474-11-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,6,4,7 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 476474-11:
(8*4)+(7*7)+(6*6)+(5*4)+(4*7)+(3*4)+(2*1)+(1*1)=180
180 % 10 = 0
So 476474-11-0 is a valid CAS Registry Number.

476474-11-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-quinolin-7-one

1.2 Other means of identification

Product number -
Other names Dihydropyrrolopyrazole,13

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:476474-11-0 SDS

476474-11-0Relevant academic research and scientific papers

Optimization of a dihydropyrrolopyrazole series of transforming growth factor-β type I receptor kinase domain inhibitors: Discovery of an orally bioavailable transforming growth factor-β receptor type I inhibitor as antitumor agent

Li, Hong-Yu,McMillen, William T.,Heap, Charles R.,McCann, Denis J.,Yan, Lei,Campbell, Robert M.,Mundla, Sreenivasa R.,King, Chi-Hsin R.,Dierks, Elizabeth A.,Anderson, Bryan D.,Britt, Karen S.,Huss, Karen L.,Voss, Matthew D.,Wang, Yan,Clawson, David K.,Yingling, Jonathan M.,Sawyer, J. Scott

, p. 2302 - 2306 (2008/12/20)

In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in vivo target inhibition paradigm is an effective approach to assess potential for antitumor efficacy. The dihydropyrrolopyrazole inhibitor 15d (LY2109761) is representative of a novel series of antitumor agents.

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