476490-05-8 Usage
Uses
Used in Industrial Applications:
3',4'-Dichlorobiphenyl-3-carbaldehyde is used as a chemical intermediate for the synthesis of various industrial products. Its unique structure, which includes a 3-carbaldehyde group and two chlorine atoms, may provide specific properties that are beneficial in certain manufacturing processes.
Used in Research and Development:
3',4'-Dichlorobiphenyl-3-carbaldehyde may be utilized in research settings to study its chemical properties, potential applications, and effects on the environment. Understanding its behavior and interactions with other compounds can help in the development of new industrial processes or products that incorporate 3',4'-DICHLOROBIPHENYL-3-CARBALDEHYDE.
Used in Environmental Studies:
Given the limited information on the toxicity levels and environmental impact of 3',4'-dichlorobiphenyl-3-carbaldehyde, it may be used in environmental studies to assess its potential effects on ecosystems and human health. This can help in the development of guidelines for its safe use and disposal, as well as in the identification of any necessary regulatory measures.
Check Digit Verification of cas no
The CAS Registry Mumber 476490-05-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,6,4,9 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 476490-05:
(8*4)+(7*7)+(6*6)+(5*4)+(4*9)+(3*0)+(2*0)+(1*5)=178
178 % 10 = 8
So 476490-05-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H8Cl2O/c14-11-4-5-12(13(15)7-11)10-3-1-2-9(6-10)8-16/h1-8H
476490-05-8Relevant academic research and scientific papers
The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds
Patel, Bhargav A.,Ashby Jr., Charles R.,Hardej, Diane,Talele, Tanaji T.
supporting information, p. 5523 - 5527 (2013/10/01)
A focused library of rhodanine compounds containing novel substituents at the C5-position was synthesized and tested in vitro against a panel of clinically relevant MRSA strains. The present SAR study was based on our lead compound 1 (MIC = 1.95 μg/mL), with a focus on identifying optimal C5-arylidene substituents. In order to obtain this objective, we condensed several unique aromatic aldehydes with phenylalanine-derived rhodanine intermediates to obtain C5-substituted target rhodanine compounds for evaluation as anti-MRSA compounds. These efforts produced three compounds with significant efficacy: 23, 32 and 44, with MIC values ranging from 0.98 to 1.95 μg/mL against all tested MRSA strains as compared to the reference antibiotics penicillin G (MIC = 15.60-250.0 μg/mL) and ciprofloxacin (MIC = 7.80-62.50 μg/mL) and comparable to that of vancomycin (MIC = 0.48 μg/mL). In addition, compounds 24, 28, 37, 41, 46 and 48 (MIC = 1.95-3.90 μg/mL) were efficacious against all MRSA strains. The majority of the synthesized compounds had bactericidal activity at concentrations only two to fourfold higher than their MIC. Overall, the results suggest that compounds 23, 32 and 44 may be of potential use in the treatment of MRSA infections.
