24209-38-9Relevant articles and documents
New adaptation diseases of cefoperazone medicinal preparation for treating endometritis and other gynecological genital tract infections
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Paragraph 0108; 0109; 0115-0126; 0141-0142, (2020/08/22)
The invention discloses new adaptation diseases of cefoperazone medicinal preparation for treating gynecological genital tract infections of gynecology department. The cefoperazone sodium provided bya specific raw material production process is extremely low in impurity content and remarkable in medicine effect, so that the quality of a preparation product is improved, the safety and effectiveness of the preparation product are guaranteed, and the invention provides the application of preparing the medicine for treating endometritis and other gynecological genital tract infections.
1/5 water cefamandole sodium compound
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Paragraph 0029; 0030, (2017/07/20)
The invention discloses a 1/5 water cefamandole sodium compound and a preparation method thereof. Each mol of cefamandole sodium compound contains 1/5 mol of water. The cefamandole sodium compound prepared by the method disclosed by the invention has low impurity content and good stability and has a wider application prospect.
A novel synthetic route to 7-MAC from 7-ACA
Xiong, Fei,Li, Gen,Song, Bo,Chen, Fen-Er,Zeng, Zhao-Sen
, p. 1019 - 1025 (2016/05/02)
An efficient and practical seven-step procedure is described for the synthesis of (6R,7S)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo [4.2.0]oct-2-ene-2-carboxylate (7-MAC, 3) with overall yield of 49?%. This synthesis features a convenient and highly selective method for the introduction of 7α-methoxy group to cephalosporin nucleus in 10 using MeOLi/t-BuOCl in THF.