476619-76-8

Basic information

• Product Name: 4-chloro-2-iodoBenzoyl chloride
• Synonyms: 4-chloro-2-iodoBenzoyl chloride
• CAS NO: 476619-76-8
• Molecular Weight: 300.911
• Mol File: 476619-76-8.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-iodoBenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-iodoBenzoyl chloride(476619-76-8)
• EPA Substance Registry System: 4-chloro-2-iodoBenzoyl chloride(476619-76-8)

Safety Data

• Hazardous Substances Data: 476619-76-8(Hazardous Substances Data)

Upstream product

• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 13421-13-1 4-chloro-2-iodobenzoic acid 

Downstream Products

• 1001351-10-5 4-chloro-2-iodo-N,N-diisopropylbenzamide 
• 1453187-86-4 ethyl (E)-3-[(Z)-1-(4-chlorophenylimino)-3-hexyl-1H-isochromen-4-yl]acrylate 
• 1453187-89-7 ethyl (E)-3-[(Z)-6-chloro-3-phenyl-1-(phenylimino)-1H-isochromen-4-yl]acrylate 
• 1453187-90-0 ethyl (E)-3-[(Z)-6-chloro-3-hexyl-1-(phenylimino)-1H-isochromen-4-yl]acrylate 
• 1377927-16-6 4-chloro-2-iodo-N-phenylbenzamide 
• 1581735-37-6 4-chloro-2-iodo-N-isopropyl-N-methylbenzamide 
• 1581735-29-6 2-isopropyl-3,3-dimethyl-5-phenylisoindolin-1-one 
• 1581735-30-9 2-methyl-3,3-dimethyl-5-phenylisoindolin-1-one 
• 1581735-31-0 2-ethyl-3,3-dimethyl-5-phenylisoindolin-1-one 
• 1581735-32-1 2'-methyl-6'-phenylspiro[cyclohexane-1,1'-isoindolin]-3'-one 
• 942319-20-2 4-chloro-2-iodobenzamide 
• 7147-90-2 4-chlorophthalimide 

Relevant articles and documents

Tetrabutylammonium Iodide (TBAI) Catalyzed Electrochemical C-H Bond Activation of 2-Arylated N -Methoxyamides for the Synthesis of Phenanthridinones

An electrochemical method for the synthesis of phenanthridinones through constant-potential electrolysis (CPE) mediated by Bu 4 NI (TBAI) is reported. The protocol is metal and oxidant free, and proceeds with 100% current efficiency. TBAI plays a dual role as both a redox catalyst and a supporting electrolyte. The intramolecular C-H activation proceeds under mild reaction conditions and with a short reaction time through electrochemically generated amidyl radicals. The reaction has been scaled up to a gram level, showing its practicability, and the synthetic utility and applicability of the protocol have been demonstrated by a direct one-step synthesis of the bioactive compound phenaglaydon.

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Diastereoselective Nickel-Catalyzed Carboiodination Generating Six-Membered Nitrogen-Based Heterocycles

A scalable, diastereoselective nickel-catalyzed carboiodination reaction is reported that avoids metal-based reducing agents. Novel anti-dihydroquinolones and previously unreported tetrahydroquinolines are now readily prepared. The generation of anti-dihydroquinolones is noteworthy, as this selectivity is opposite to that of the Pd variant. Mechanistic insight into the nature of the nickel-catalyzed carboiodination reaction was derived experimentally, suggesting a catalyst-controlled cyclization and stereoretentive reductive elimination.