476622-86-3

Upstream product

• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 476623-33-3 7-benzyloxy-3-bromo-4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 
• 476623-04-8 7-benzyloxy-4-[1-(tert-butyl-dimethyl-silanyloxymethyl)-vinyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 
• 476623-32-2 7-benzyloxy-4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 
• 476623-00-4 7-benzyloxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 
• 476623-31-1 7-benzyloxy-4-bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 
• 476622-92-1 7-benzyloxy-4-bromoindole 
• 383868-64-2 1-(benzyloxy)-4-bromo-2-nitrobenzene 

Downstream Products

• 476623-35-5 1-amino-3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-butan-2-one 
• 476623-26-4 3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-1-nitro-butan-2-one 
• 476623-19-5 3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-1-bromo-butan-2-one 
• 476623-34-4 3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-1-diazo-butan-2-one 
• 476623-18-4 2-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-propionic acid 
• 476623-24-2 2-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-propionaldehyde 
• 476623-27-5 3-{7-benzyloxy-3-[5-(6-bromo-1H-indol-3-yl)-6-methoxy-pyrazin-2-yl]-1H-indol-4-yl}-1-nitro-butan-2-one 
• 476622-84-1 7-Benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 

Relevant academic research and scientific papers

The first total synthesis of dragmacidin D

The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine- and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to the completion of the natural product.