476623-00-4Relevant articles and documents
The first total synthesis of dragmacidin D
Garg, Neil K.,Sarpong, Richmond,Stoltz, Brian M.
, p. 13179 - 13184 (2007/10/03)
The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine- and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to the completion of the natural product.