476667-23-9Relevant academic research and scientific papers
Binding affinities of oligonucleotides and PNAs containing phenoxazine and G-clamp cytosine analogues are unusually sequence-dependent
Ortega, Jose-Antonio,Blas, Jose Ramon,Orozco, Modesto,Grandas, Anna,Pedroso, Enrique,Robles, Jordi
, p. 4503 - 4506 (2008/03/13)
(Chemical Equation Presented) Melting temperatures of DNA duplexes containing the phenoxazine (P) and G-clamp (X) cytosine analogues exhibited a strong and unusual dependence on the nucleoside flanking the modified nucleobase, and the same trend was obser
Synthesis of amino- and guanidino-G-clamp PNA monomers
Ausin, Cristina,Ortega, Jose-Antonio,Robles, Jordi,Grandas, Anna,Pedroso, Enrique
, p. 4073 - 4075 (2007/10/03)
(matrix presented) Syntheses of the protected amino- and guanidino-G-clamp PNA monomers, 9a and 9b, respectively, have been accomplished in eight steps from 5-bromouracil. Enhanced stacking interactions and additional hydrogen bonds with guanine should in
