476681-59-1

Basic information

• Product Name: Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-
• CAS NO: 476681-59-1
• Molecular Formula: C15H8BrCl2N
• Molecular Weight: 353.045
• Mol File: 476681-59-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-(476681-59-1)
• EPA Substance Registry System: Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-(476681-59-1)

Safety Data

• Hazardous Substances Data: 476681-59-1(Hazardous Substances Data)

Upstream product

• 502841-10-3 3-bromo-2-(4'-chlorophenyl)quinolin-4(1H)-one 
• 78396-10-8 2-(4’-chlorophenyl)-4-quinolone 

Downstream Products

• 1079284-22-2 4-azido-3-bromo-2-(4-chlorophenyl)quinoline 

Relevant articles and documents

2-Aryl-4-azido-3-(bromo/iodo)quinolines as substrates for the synthesis of primary 4-amino-2,3-disubstituted quinoline derivatives

(Chemical Equation Presented) Staudinger reaction of the 2-aryl-4-azido-3-bromoquinolines and 2-aryl-4-azido-3-iodoquinolines with triphenyl phosphine in refluxing tetrahydrofuran afforded series of 2-aryl-3-halogeno-4-(triphenylphosphoranylideneamino)quinolines. The latter were, in tum, hydrolyzed to the corresponding primary 4-amino-2-aryl-3-(bromo/ iodo)quinolines using 80% acetic acid under reflux. Tetrakis(triphenylphosphine) palladium(0)-catalyzed Suzuki reaction of the 2-aryl-3-iodo-4- (triphenylphosphoranylideneamino)quinolines with phenylboronic acid in dimethyl formamide in the presence of 2 M K2CO3 followed by hydrolysis of the incipient 2,3-diaryl-4-(triphenylphosphoranylideneamino) quinolines with 80% acetic acid afforded the 4-amino-2,3-diarylquinolines.

Dimethyl sulfoxide-promoted dehydrosulfonylation of 2-aryl-3-bromo-1-methanesulfonyl-2,3-dihydroquinolin-4(1H)-ones

The 2-aryl-3-bromo-l-methanesulfonyl-2,3-dihydroquinolin-4(1H)-ones undergo dimethyl sulfoxide (DMSO)-promoted dehydrosulfonylation under reflux at 130-140°C to afford the corresponding 2-aryl-3-bromoquinolin-4(1H)-ones.