4770-38-1

Usage

Uses

Used in Pharmaceutical Research:
1H-INDOL-7-OL,2,3-DIHYDRO is used as a key intermediate in pharmaceutical research for its potential role in the development of new drugs. Its unique structure allows it to be a building block in the synthesis of pharmaceutical drugs and other organic compounds, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-INDOL-7-OL,2,3-DIHYDRO serves as a valuable precursor compound. Its reactivity and structural features make it suitable for the creation of a wide range of organic compounds, thus expanding the scope of chemical reactions and product development.
Used in Antimicrobial Applications:
1H-INDOL-7-OL,2,3-DIHYDRO is utilized as an antimicrobial agent, leveraging its biological activity to combat various microorganisms. This application is crucial in the development of new antibiotics and antifungal agents to address the growing issue of antibiotic resistance.
Used in Anti-Inflammatory Applications:
1H-INDOL-7-OL,2,3-DIHYDRO is also used as an anti-inflammatory agent, where its biological activities help in reducing inflammation. This makes it a potential candidate for the treatment of various inflammatory conditions and diseases.
Used in Anti-Cancer Applications:
1H-INDOL-7-OL,2,3-DIHYDRO has been studied for its anti-cancer properties, making it a candidate for use in oncology research. Its potential to target and inhibit cancer cell growth without harming normal cells positions it as a promising agent in the development of novel cancer therapies.

Upstream product

• 105205-62-7 2-(2,3-Dihydro-1H-indol-7-yl)-propan-2-ol 
• 2380-84-9 7-Indolol 
• 847976-13-0 pyrrolobenzoxazine-2,5-dione 
• 105205-61-6 1-(2,3-Dihydro-1H-indol-7-yl)-ethanol 

Downstream Products

• 2380-84-9 7-Indolol 
• 4770-36-9 1-acetyl-2,3-dihydro-7-hydroxyindole 

Relevant academic research and scientific papers

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.

Convenient synthesis of 7-hydroxyindole

7-Hydroxyindole, the key building block for the synthesis of AJ-9677 1, was prepared from indoline in six steps in 36% overall yield. AJ-9677 1 is a potent and selective adrenaline β3-agonist being considered as a clinical candidate to treat obesity in those who are suffering from diabetes.

FURTHER OBSERVATIONS ON THE LEWIS ACID-CATALYZED BENZYLIC HYDROPEROXIDE REARRANGEMENT: USE OF A BORON-TRIFLUORIDE/HYDROGEN PEROXIDE PREFORMED, AGED REAGENT

A preformed, aged reagent derived from boron trifluoride etherate and 90percent hydrogen peroxide (2:1-4:1 complex) has been found to be a useful reagent for promoting the benzylic hydroperoxide rearrangement of readily oxidizable substrates bearing a free, basic amine.The use of this procedure for introduction of the C-4 phenol of the C-4/C-5 selectively-protected o-catechol unit found in PDE-I and PDE-II, naturally-occuring phosphodiesterase inhibitors constituting the central and right-hand segments of the antitumor-antibiotic CC-1065, is detailed.