4771-51-1Relevant articles and documents
Synthesis of indoloquinolines: An intramolecular cyclization leading to advanced perophoramidine-relevant intermediates
Cordes, David B.,Johnston, Craig A.,Lebl, Tomas,Slawin, Alexandra M. Z.,Westwood, Nicholas J.
, (2021/10/12)
The bioactive natural product perophoramidine has proved a challenging synthetic target. An alternative route to its indolo[2,3-b]quinolone core structure involving a N-chlorosuccinimde-mediated intramolecular cyclization reaction is reported. Attempts to progress towards the natural product are also discussed with an unexpected deep-seated rearrangement of the core structure occurring during an attempted iodoetherification reaction. X-ray crystallographic analysis provides important analytical confirmation of assigned structures.
