4792-72-7

Basic information

• Product Name: 5,7-DICHOROINDOLE
• Synonyms: 5,7-DICHOROINDOLE;5,7-DICHLOROINDOLE;5,7-DICHLORO-1H-INDOLE;5,7-dichloro-7aH-indole;1H-Indole,5,7-dichloro-;5,7-Dichrorindole
• CAS NO: 4792-72-7
• Molecular Formula: C8H5Cl2N
• Molecular Weight: 186.038
• Product Categories: Indoles and derivatives;Indoles;CHIRAL CHEMICALS
• Mol File: 4792-72-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 328.1 °C at 760 mmHg
• Flash Point: 182.2 °C
• Appearance: /
• Density: 1.479 g/cm³
• Vapor Pressure: 0.000236mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.51±0.30(Predicted)
• CAS DataBase Reference: 5,7-DICHOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DICHOROINDOLE(4792-72-7)
• EPA Substance Registry System: 5,7-DICHOROINDOLE(4792-72-7)

Safety Data

• Hazardous Substances Data: 4792-72-7(Hazardous Substances Data)

Usage

General Description

5,7-Dichloroindole is a synthetic organic compound distinguished by the presence of two chlorine atoms on its indole ring structure at the 5th and 7th positions. Indole derivatives like 5,7-dichloroindole are commonly used in the pharmaceutical industry due to their versatility and biological activity. 5,7-Dichloroindole itself has applications in research and development, playing key roles in the synthesis of complex pharmacological compounds. Despite its utility, this compound, like many chlorinated hydrocarbons, should be handled with caution due to potential toxicity.

InChI:InChI=1/C8H5Cl2N/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,8H

Upstream product

• 4792-71-6 5,7-dichloro-1H-indole-2-carboxylic acid 
• 611-06-3 2,4-dichloronitrobenzene 
• 3536-96-7 vinylmagnesium chloride 
• 684250-19-9 2,4-dichloro-6-trimethylsilanylethynylaniline 
• 697-86-9 2,4-dichloro-6-bromoaniline 
• 4792-70-5 5,7-dichloro-indole-2-carboxylic acid ethyl ester 
• 78-94-4 methyl vinyl ketone 
• 684250-09-7 2,4-dichloro-6-ethynylphenylamine 

Downstream Products

• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 1259890-94-2 5-chloro-7-(4-methoxyphenyl)indole 
• 4771-51-1 5,7-dichloroindole-3-carbaldehyde 

Relevant articles and documents

Synthesis of indoloquinolines: An intramolecular cyclization leading to advanced perophoramidine-relevant intermediates

The bioactive natural product perophoramidine has proved a challenging synthetic target. An alternative route to its indolo[2,3-b]quinolone core structure involving a N-chlorosuccinimde-mediated intramolecular cyclization reaction is reported. Attempts to progress towards the natural product are also discussed with an unexpected deep-seated rearrangement of the core structure occurring during an attempted iodoetherification reaction. X-ray crystallographic analysis provides important analytical confirmation of assigned structures.

SUBSTITUTED INDOLE DERIVATIVES

Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Gold(III)-catalyzed annulation of 2-alkynylanilines: A mild and efficient synthesis of indoles and 3-haloindoles

Gold(III)-catalyzed annulation of 2-alkynylanilines in EtOH or EtOH-water mixtures at room temperature gives indoles derivatives in good yields. One-flask protocol for the gold-catalyzed conversion of 2-alkynylanilines to 3-bromo and 3-iodoindoles is also reported.