Ipilimumab, also known by its brand name Yervoy, is a CTLA-4 blocking antibody that was approved by the U.S. FDA in March 2011 for the treatment of unresectable or metastatic melanoma. It has an indirect effect on tumors by blocking CTLA-4 negative signaling and augmenting T-cell activity, making it one of the few immunostimulatory drugs approved for cancer therapy.
477202-00-9
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Basic information
- Product Name: ipilimumab
- Synonyms: ipilimumab
- CAS NO:477202-00-9
- Molecular Formula:
- Molecular Weight:
- EINECS: N/A
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Chemical Properties
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- Solubility: N/A
- CAS DataBase Reference: ipilimumab(CAS DataBase Reference)
- NIST Chemistry Reference: ipilimumab(477202-00-9)
- EPA Substance Registry System: ipilimumab(477202-00-9)
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Safety Data
- Hazard Codes: N/A
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- PackingGroup: N/A
- Hazardous Substances Data: 477202-00-9(Hazardous Substances Data)
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477202-00-9 Usage
Uses
Used in Oncology:Ipilimumab is used as an immunostimulatory drug for the treatment of unresectable or metastatic melanoma. It works by blocking the CTLA-4 negative signaling and enhancing T-cell activity, which helps the immune system to fight against cancer cells.
Used in HIV Infection Treatment:
Ipilimumab is also used as a potential treatment option for HIV infection. Its immunostimulatory properties may help in modulating the immune response and improving the overall health of patients with HIV.
Clinical Use
Antineoplastic agent: Treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapyMetabolism
Most likely removed by opsonisation via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.Check Digit Verification of cas no
The CAS Registry Mumber 477202-00-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,7,2,0 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.Calculate Digit Verification of CAS Registry Number 477202-00:
(8*4)+(7*7)+(6*7)+(5*2)+(4*0)+(3*2)+(2*0)+(1*0)=139
139 % 10 = 9
So 477202-00-9 is a valid CAS Registry Number.
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477202-00-9Downstream Products
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ipilimumab
