477312-85-9

Usage

Uses

Used in Organic Synthesis:
TERT-BUTYL [(1S)-1-(3-BROMOPHENYL)ETHYL]CARBAMATE is used as a building block in organic synthesis for the preparation of various biologically active compounds. Its unique structure, including the tert-butyl group, bromophenyl group, and carbamate functional group, provides steric hindrance, stability, and reactivity, making it suitable for the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, TERT-BUTYL [(1S)-1-(3-BROMOPHENYL)ETHYL]CARBAMATE is used as a key intermediate in the development of new drugs. Its versatile reactivity and potential pharmacological properties make it an attractive candidate for medicinal chemistry and drug discovery processes. Researchers can exploit its chemical modifications to design and synthesize novel therapeutic agents with improved efficacy and selectivity.
Used in Medicinal Chemistry:
TERT-BUTYL [(1S)-1-(3-BROMOPHENYL)ETHYL]CARBAMATE is employed in medicinal chemistry for the design and synthesis of biologically active molecules with potential therapeutic applications. Its unique structural features, such as the tert-butyl group and bromophenyl group, allow for the development of compounds with enhanced stability and selectivity towards specific biological targets.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 74877-08-0 (S)-1-(3-bromophenyl)ethanamine 

Downstream Products

• 701938-93-4 (S)-[1-(3-[1,4]-oxazepan-4-yl-phenyl)ethyl]-carbamic acid tert-butyl ester 
• 840475-07-2 {1-[3-(6-fluoro-pyridin-3-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 477312-94-0 (S)-1-[3-(6-fluoro-pyridin-3-yl)-phenyl]-ethylamine 
• 477312-35-9 (S)-[1-(3-morpholin-4-yl-phenyl)ethyl]-carbamic acid tert-butyl ester 
• 697804-15-2 (S)-[1-(3-Formyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 477313-02-3 (S)-{1-[3-(4-methylpiperazin-4-yl)phenyl]ethyl}-carbamic acid tert-butyl ester 
• 701914-08-1 {1-[3-(1-amino-ethyl)-phenyl]-pyrrolidin-3-yl}-dimethyl-amine 
• 701913-93-1 (S)-2-phenyl-cyclopropanecarboxylic acid [1-(3-pyridin-3-yl-phenyl)-ethyl]-amide 
• 477312-97-3 (S)-1-(3-Pyrimidin-5-yl-phenyl)-ethylamine 
• 697804-11-8 (S)-1-(3-thiazol-2-yl-phenyl)-ethylamine 
• 697804-01-6 (S,S)-amino-N-[1-(3-pyridin-3-yl-phenyl)-ethyl]-propionamide 
• 697803-55-7 (S)-2-Dimethylamino-N-[1-(3-pyridin-3-yl-phenyl)-ethyl]-acetamide 

Relevant academic research and scientific papers

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis

The synthesis, structure-activity relationships (SAR) and biological evaluation of thiazole based tricyclic inhibitors of IKK2 are described. Compound 9 was determined to be orally efficacious in a murine model of rheumatoid arthritis.

PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION

The present invention relates to novel compounds that inhibit the production of β- amyloid peptide (1-42), processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.

3-Heterocyclic benzylamide derivatives as potassium channel openers

The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I wherein R1, R2, R3, R4, R5, R6, A and Het are as defined in the specifi

Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers

A new class of acrylamides was synthesized, and the effects of these analogues on outward potassium current were evaluated by using two electrode voltage clamp recordings from Xenopus laevis oocytes expressing cloned mKCNQ2 channels. SAR studies indicated that the pharmacophore of the acrylamide series includes the (S) absolute configuration at the (1-phenyl)ethyl moiety and the α,β-unsaturated acrylamide functionality with a free NH. This study identified (S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide ((S)-1) and (S)-N-[1-(4-fluoro-3-morpholin-4-yl-phenyl)-ethyl]-3- (4-fluoro-phenyl)-acrylamide ((S)-2) as KCNQ2 openers for further electrophysiological evaluations. These two acrylamides demonstrated significant activity in the cortical spreading depression model of migraine as we reported previously.

3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers

The present invention provides piperazinyl phenylethyl amides and related derivatives having the general Formula I wherein R1, R2, R3, R4, R5, R6, A and B are as defined in the specificatio

Arylcyclopropylcarboxylic amides as potassium channel openers

The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined