477331-81-0

Basic information

• Product Name: (S)-1-[(S)-3-tert-Butoxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester
• CAS NO: 477331-81-0
• Molecular Weight: 566.866
• Mol File: 477331-81-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-1-[(S)-3-tert-Butoxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[(S)-3-tert-Butoxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester(477331-81-0)
• EPA Substance Registry System: (S)-1-[(S)-3-tert-Butoxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester(477331-81-0)

Safety Data

• Hazardous Substances Data: 477331-81-0(Hazardous Substances Data)

Upstream product

• 446064-60-4 3-tert-butoxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid 
• 41324-66-7 H-Pro-OBzl 
• 24424-99-5 di-tert-butyl dicarbonate 
• 78221-36-0 Teoc-aspargine 
• 73259-80-0 N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid 

Downstream Products

• 446064-63-7 C₅₈H₆₂Cl₃N₈O₁₁P 
• 446064-72-8 C₆₅H₉₀Cl₃N₉O₁₆Si 
• 446064-67-1 C₆₈H₉₄Cl₃N₉O₁₆Si 

Relevant articles and documents

Total synthesis of cyclotheonamides E2 and E3: Application of cyano ylide methodology

A total synthesis of cyclotheonamides E2 and E3 is reported. A key step in the synthesis involves the formation of the α-keto amide linkage by application of the cyano ylide activation of a carboxyl group as developed in our earlier syntheses of cyclic peptides in the family of protease inhibitors.