477333-84-9Relevant academic research and scientific papers
Stereoselective Construction of γ-Lactams via Copper-Catalyzed Borylacylation
Bajohr, Jonathan,Lautens, Mark,Polishchuk, Iuliia,Torelli, Alexa,Whyte, Andrew
supporting information, p. 7915 - 7919 (2020/11/02)
A versatile and highly stereoselective borylative cyclization to generate polyfunctionalized γ-lactams has been developed. The stereoselective synthesis of these key ring systems is crucial due to their ubiquity in natural products. We report the diastero- and enantioselective construction of di- and trisubstituted γ-lactam cores, with examples containing an enantioenriched quaternary carbon.
