3-(4-Methoxyanilino)-1-(2-naphthyl)-1-propanone

Base Information

• Chemical Name: 3-(4-Methoxyanilino)-1-(2-naphthyl)-1-propanone
• CAS No.: 477333-84-9
• Molecular Formula: C₂₀H₁₉NO₂
• Molecular Weight: 305.376
• European Community (EC) Number: 651-017-0
• DSSTox Substance ID: DTXSID301195904
• Mol file: 477333-84-9.mol

Synonyms:477333-84-9;3-(4-methoxyanilino)-1-(2-naphthyl)-1-propanone;3-((4-Methoxyphenyl)amino)-1-(naphthalen-2-yl)propan-1-one;3-[(4-methoxyphenyl)amino]-1-(naphthalen-2-yl)propan-1-one;3-(4-methoxyanilino)-1-naphthalen-2-ylpropan-1-one;DTXSID301195904;AKOS005108407;JS-2497;3-[(4-Methoxyphenyl)amino]-1-(2-naphthalenyl)-1-propanone

Chemical Property of 3-(4-Methoxyanilino)-1-(2-naphthyl)-1-propanone

Chemical Property:

• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 305.141578849
• Heavy Atom Count: 23
• Complexity: 376

Purity/Quality:

3-(4-METHOXYANILINO)-1-(2-NAPHTHYL)-1-PROPANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NCCC(=O)C2=CC3=CC=CC=C3C=C2

Technology Process of 3-(4-Methoxyanilino)-1-(2-naphthyl)-1-propanone

There total 2 articles about 3-(4-Methoxyanilino)-1-(2-naphthyl)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-naphthyl ketone (93-08-3) → C20H19NO2 (477333-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 48 h / Reflux

2: ethanol; water / 0.72 h / Reflux; Inert atmosphere

With hydrogenchloride; In ethanol; water;

DOI:10.1021/acs.orglett.0c02837

Reference yield:

3-dimethylamino-1-(naphthalen-2-yl)propan-1-one hydrochloride (2631-61-0) + 4-methoxy-aniline (104-94-9) → C20H19NO2 (477333-84-9)

Guidance literature:

In ethanol; water; for 0.72h; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02837

Reference yield:

methyl-triphenylphosphonium iodide (2065-66-9) + C20H19NO2 (477333-84-9) → C21H21NO

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.3h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02837

upstream raw materials:

methyl 2-naphthyl ketone

3-dimethylamino-1-(naphthalen-2-yl)propan-1-one hydrochloride

4-methoxy-aniline