477352-24-2

Basic information

• Product Name: 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate
• Synonyms: 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate
• CAS NO: 477352-24-2
• Molecular Weight: 351.445
• Mol File: 477352-24-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate(477352-24-2)
• EPA Substance Registry System: 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate(477352-24-2)

Safety Data

• Hazardous Substances Data: 477352-24-2(Hazardous Substances Data)

Upstream product

• 398476-50-1 C₂₀H₂₃NO₂ 
• 64-17-5 ethanol 
• 477352-23-1 C₂₀H₂₀N₂O 

Downstream Products

• 1355357-59-3 [18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] 
• 1355357-58-2 [(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate 
• 1355357-56-0 3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] 
• 1355357-55-9 1'-(4-fluorobenzyl)-3-methyl-3H-spiro[[2]benzofuran-1,4'-piperidine] 
• 1355357-54-8 1'-(4-fluorobenzyl)-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] 
• 747353-15-7 3-methyl-3H-spiro[[2]benzofuran-1,4'-piperidine] 
• 1355357-53-7 3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] 

Relevant articles and documents

Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for central σ1 receptors and comparison with fluoroalkyl homologs

The spirocyclic σ1 receptor ligand 1 (1′-benzyl-3- (fluoromethyl)-3H-spiro[[2]benzofuran-1,4′-piperidine]) was prepared in four steps starting from methoxy derivative 5. Due to its high σ1 affinity (Ki = 0.74 nM) and selec