477575-60-3Relevant academic research and scientific papers
Simple and facile l-prolinamides derived from achiral cycloalkylamines as organocatalysts for the highly efficient large-scale asymmetric direct aldol reactions
Xu, Jiang-Wei,Fu, Xiang-Kai,Hu, Xiao-Yan,Wu, Chuan-Long
experimental part, p. 1156 - 1163 (2012/06/18)
A series of N-cycloalkylprolinamides have been designed and synthesized from achiral cycloalkylamines in a facile manner. They promoted high stereoselectivity in the cross-aldol reaction. N-cyclopropylprolinamide performed best with a smallest carbocyclic
Simple, inexpensive, and facile l-prolinamide used as a recyclable organocatalyst for highly efficient large-scale asymmetric direct aldol reactions
Xu, Jiangwei,Fu, Xiangkai,Wu, Chuanlong,Hu, Xiaoyan
experimental part, p. 840 - 850 (2011/08/21)
In order to discover a simple, inexpensive, and efficient route to obtain highly enantiomerically enriched anti-aldol products for applications in industry, a series of prolinamides 1-5 with different carbocyclic rings have been synthesized from achiral c
Enantioselective cyanosilylation of α,α-dialkoxy ketones catalyzed by proline-derived in-situ-prepared N-oxide as bifunctional organocatalyst
Qin, Bo,Liu, Xiaohua,Shi, Jian,Zheng, Ke,Zhao, Haitao,Feng, Xiaoming
, p. 2374 - 2378 (2007/10/03)
Bifunctional N,N′-dioxide catalysts have been developed for highly enantioselective cyanosilylation of α,α-dialkoxy ketones. This process, catalyzed by in-situ-prepared proline-derived N,N′-dioxide 2b, produced the corresponding cyanohydrin trimethylsilyl ethers in excellent yields (up to 99%) with high enantioselectivities (up to 93% ee). A reasonable mechanism was proposed according to the observation of the linear effect, 1H NMR spectra, isolated cyanohydrin, and the roles of the NH and N-oxide moieties of the catalyst.
5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS
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, (2008/06/13)
The present invention relates to certain 5-aralkylsulfonyl-3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
