477584-32-0Relevant articles and documents
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Sheppeck II, James E.,Gilmore, John L.,Yang, Anle,Chen, Xiao-Tao,Xue, Chu-Biao,Roderick, John,Liu, Rui-Qin,Covington, Maryanne B.,Decicco, Carl P.,Duan, James J.-W.
, p. 1413 - 1417 (2007)
A series of novel hydantoins was designed and synthesized as structural alternatives to hydroxamate inhibitors of TACE. 5-Mono- and di-substituted hydantoins exhibited activity with IC50 values of 11-60 nM against porcine TACE in vitro and excellent selectivity against other MMPs.