4776-15-2Relevant academic research and scientific papers
Cyclocondensation Of 4-Hydroxy-5,6-Diaminopyrimidine With α,β-Dihalochalcones
Kolos, N. N.,Orlov, V. D.,Yur'eva, E. Yu.,Zhidkova, E. V.
, p. 1210 - 1214 (1993)
The condensation of 4-hydroxy-5,6-diaminopyrimidine with 1,3-diaryl-2,3-dihalopropanones and with dibenzoylacetylenes was used to obtain derivatives of 1H-pyrimido-1,5-diazepine and pyrimidopyrazine, respectively.Their spectral characteristics were studied, and the directions in the formation of 7- and 6-membered heterocycles were determined.The synthesized pyrimidopyrazines exist in the form of two tautomeric species - enaminocarbinol and enol forms, with an intramolecular hydrogen bond of the chelate type.
A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage
Djuidje, Ernestine N.,Dissette, Valeria,Bino, Alessia,Benetti, Simonetta,Balzarini, Jan,Liekens, Sandra,Manfredini, Stefano,Vertuani, Silvia,Baldisserotto, Anna
, p. 760 - 769 (2017/05/26)
Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Across the solar radiation spectrum, UV light is the main cause behind skin problems. In the search for novel photoprotective compounds, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All title compounds were investigated for their UV filtering, antioxidant, antifungal, and antiproliferative activities. For the photoprotection assays we used a diffuse transmittance technique to determine the sun protection factor (SPF) in vitro, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) tests for evaluating the antioxidant activity of the more potent compounds. Among them, 8-(2,5-dihydroxyphenyl)-7H-purin-6-ol (compound 26) proved to be a good radical scavenger and is also endowed with broad-spectrum UVA filtering capabilities, suitable for further development as a protective molecule.
