477710-52-4

Basic information

• Product Name: 1-BENZYL-2-(1H-PYRAZOL-3-YL)-1H-1,3-BENZIMIDAZOLE
• Synonyms: 1-BENZYL-2-(1H-PYRAZOL-3-YL)-1H-1,3-BENZIMIDAZOLE;1-benzyl-2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole
• CAS NO: 477710-52-4
• Molecular Formula: C₁₇H₁₄N₄
• Molecular Weight: 274.32
• Mol File: 477710-52-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-2-(1H-PYRAZOL-3-YL)-1H-1,3-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-2-(1H-PYRAZOL-3-YL)-1H-1,3-BENZIMIDAZOLE(477710-52-4)
• EPA Substance Registry System: 1-BENZYL-2-(1H-PYRAZOL-3-YL)-1H-1,3-BENZIMIDAZOLE(477710-52-4)

Safety Data

• Hazardous Substances Data: 477710-52-4(Hazardous Substances Data)

Upstream product

• 1333247-00-9 1-(1H-benzo[d]imidazole-2-yl)-3-(dimethylamino)prop-2-en-1-one 
• 380653-63-4 2-(1H-pyrazol-3-yl)-1H-benzoimidazole 
• 100-44-7 benzyl chloride 
• 939-70-8 2-acetylbenzimidazole 
• 1333247-05-4 C₁₉H₁₉N₃O 
• 56653-41-9 1-(1-benzyl-1H-benzo[d]imidazol-2-yl)ethan-1-one 

Relevant articles and documents

Alkylation studies on pyrazolyl and isoxazolyl benzimidazoles

2-Acetylbenzimidazole (1) on heating with dimethyl formamide dimethyl acetal gave 1-(1 H-benzimidazolyl)-3-dimethylaminopropenone (2) which on reaction with hycirazpne hydrate gave 2-(1 H-pyrazolyl)-1 H-benzimidazole (3), The reaction of 3 with DMS/DES/ PhCH2CI in CH3CN containing K2CO3 as base and triethylbenzylammonium chloride (TEBAC) as phase trasfer catalyst (PTC) resulted in the formation of 2-(3-pyrazolyl)-1 - substitutedbenzimidazole (4). Alkylation of I with DMS/DES/PhCH2CI under PTC conditions gave the previously known 1-substituted -2-acetyl benzimidazoles (5) which with DMF-DMA gave I -substituted-2-(2-benzimidazolyl)-3.dimethylaminopropenone (6). The latter could also be obtained from 2 by alkylation under PTC conditions. Treatment of 6 with hydrazine hydrate in methanol yielded 4. Reaction of 2 with hydroxylammonium chloride yielded 1 H-(2-benzimidazolyl)-3-isoxazole (8) which on alkylation under PTC conditions gave 1-substituted (2-benzimidazolyl)-3-isoxazole (9). The latter could also be obtained from 6 by treatment with hydroxylammonium chloride.