56653-41-9

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 20 carbon (C) atoms, 17 hydrogen (H) atoms, 3 nitrogen (N) atoms, and 1 oxygen (O) atom.

Explanation

Benzyl derivatives are a group of organic compounds that contain a benzyl group, which is a phenylmethyl group (C6H5-CH2-). 1-(1-BENZYL-1H-BENZOIMIDAZOL-2-YL)-ETHANONE belongs to this class due to the presence of a benzyl group in its structure.

Explanation

The compound is a solid at room temperature and has a light yellow color.

Explanation

The molecular weight is the mass of one mole of a substance, calculated by adding the atomic weights of all the atoms in the molecule. In this case, the molecular weight is 315.37 grams per mole.

Explanation

Due to its unique structure and reactivity, 1-(1-Benzyl-1H-benzoimidazol-2-yl)-ethanone is often used as a starting material or intermediate in the synthesis of various pharmaceuticals and other organic compounds.

Explanation

The compound may have potential applications in the field of medicinal chemistry and drug development due to its unique structure and reactivity, which could be exploited to design new drugs or drug candidates.

Explanation

Although the compound has potential applications in various fields, more research and testing are needed to fully understand its properties, reactivity, and potential uses in different applications.

Class

Benzyl derivatives

Structure

Contains a benzimidazole and an ethanone group

Physical State

Light yellow solid

Molecular Weight

315.37 g/mol

Applications

Synthesis of pharmaceuticals and organic compounds

Potential Applications

Medicinal chemistry and drug development

Further Research

Required to fully understand properties and potential uses

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 4981-92-4 1-benzylbenzimidazole 
• 201230-82-2 carbon monoxide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 51-17-2 benzoimidazole 
• 100-39-0 benzyl bromide 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 56653-47-5 N-benzyl-2-(α-hydroxyethyl)benzimidazole 
• 100-44-7 benzyl chloride 
• 939-70-8 2-acetylbenzimidazole 

Downstream Products

• 56653-44-2 1-(1-benzyl-1H-benzoimidazol-2-yl)-2-bromo-ethanone 
• 56653-47-5 N-benzyl-2-(α-hydroxyethyl)benzimidazole 
• 1333247-05-4 C₁₉H₁₉N₃O 
• 477710-52-4 C₁₇H₁₄N₄ 
• 1333247-07-6 C₁₇H₁₃N₃O 

Relevant academic research and scientific papers

Carbonylative Acetylation of Heterocycles

Herein, a new procedure for the carbonylative acetylation of heterocycles has been developed. In this process, organic peroxide acts as the methyl source. Various heterocycles were transformed into the corresponding methyl heterocyclic ketones in moderate to good yields.

A New Facile Sulfenylation of 2-Acetylbenzimidazoles

A facile sulfenylation of 2-acetylbenzimidazoles has been achieved by using N-(phenylthio)phthalimide in the presence of potassium tert-butoxide in DMSO. The latter gave N-alkyl-β-phenylsulfenyl-2-acetylbenzimidazole on reaction with alkylating agents in the presence of potassium carbonate in N,N-dimethylformamide.

A green and simple synthesis of N-alkyl-2-acetylbenzimidazoles

A green and simple synthesis of N-alkyl-2-substituted benzimidazoles has been developed. In this method, 2-acetyl benzimidazole compound (1) was alkylated with reagents such as dimethyl sulfate/diethyl sulfate/benzyl chloride under green conditions i.e., by physical grinding in presence of a mild base like K2CO3 or by using green solvents like PEG-600, ethanol etc. or by using micro-wave irradiation technique to obtain N-alkyl-2-acetylbenzimidazoles compound (2).

Alkylation studies on pyrazolyl and isoxazolyl benzimidazoles

2-Acetylbenzimidazole (1) on heating with dimethyl formamide dimethyl acetal gave 1-(1 H-benzimidazolyl)-3-dimethylaminopropenone (2) which on reaction with hycirazpne hydrate gave 2-(1 H-pyrazolyl)-1 H-benzimidazole (3), The reaction of 3 with DMS/DES/ PhCH2CI in CH3CN containing K2CO3 as base and triethylbenzylammonium chloride (TEBAC) as phase trasfer catalyst (PTC) resulted in the formation of 2-(3-pyrazolyl)-1 - substitutedbenzimidazole (4). Alkylation of I with DMS/DES/PhCH2CI under PTC conditions gave the previously known 1-substituted -2-acetyl benzimidazoles (5) which with DMF-DMA gave I -substituted-2-(2-benzimidazolyl)-3.dimethylaminopropenone (6). The latter could also be obtained from 2 by alkylation under PTC conditions. Treatment of 6 with hydrazine hydrate in methanol yielded 4. Reaction of 2 with hydroxylammonium chloride yielded 1 H-(2-benzimidazolyl)-3-isoxazole (8) which on alkylation under PTC conditions gave 1-substituted (2-benzimidazolyl)-3-isoxazole (9). The latter could also be obtained from 6 by treatment with hydroxylammonium chloride.

Solid phase synthesis of benzimidazole ketones and benzimidazole chalcones under solvent-free conditions

Oxidation of 1-alkyl/aralkyl-2-(α-hydroxyalkyl/aryl)benzimidazoles 1 with KMnO4 on neutral alumina under solid phase conditions gives the corresponding ketones, 1-alkyl/aralkyl-2-acyl-benzimidazoles 2. Compound 2a (R2 = CH3) on condensation with aromatic aldehydes in the presence of solid NaOH under solvent-free conditions, yields the corresponding chalcones, 1-alkyl/aralkyl-2-benzimidazole aryl vinyl ketone 3.

Benzimidazolium dichromates: Efficient reagents for selective oxidation of alcohols to carbonyl compounds

Benzimidazolium dichromates have been used for the selective and efficient oxidation of simple alcohols to carbonyl compounds. 2-Methylbenzimidazolium dichromate has been used as a standard compound. It has been found to oxidize selectively, primary alcohols to aldehydes, without any over-oxidation, and secondary alcohols to ketones. Of the several solvents explored, acetic acid at RT has been found to be the best medium for oxidation.

An unusual resistance to α-bromination by arylacetyl compound: Studies on bromination of 2-acetylbenzimidazoles and their subsequent reactions with sulphur nucleophiles - Synthesis of novel β-ketosulphone derivatives of benzimidazoles

Condensation of o-phenylenediamine with lactic acid under Phillips' conditions gave the known 2(α-hydroxyethyl)benzimidazole 1 which on oxidation with acid dichromate furnishes 2-acetylbenzimidazole 2. Reaction of 2 with bromine in acetic acid at room temp. give a novel product 3 but not the expected 2-(α-bromoacetyl)benzimidazole 4. Rational explanation is offered for this anamolous behaviour of 2. Compound 2 on alkylation, give 1- alkyl derivatives which undergo smooth bromination with bromine in acetic acid to give the corresponding 1-alkyl-2(α-bromoacetyl)benzimidazoles. Reactions of latter with sulphur nucleophiles such as PhS-, ArSO2- etc., resulting in substitution of bromine, leading to novel β-ketosulphone derivatives of benzimidazoles, are reported. Products have been characterised by IR, NMR (1H and 13C) and mass spectral data.