477741-54-1

Upstream product

• 1778-09-2 4-(Methylthio)acetophenone 
• 134731-32-1 1-[4-(methylthio)phenyl]-4,4,4-trifluorobutane-1,3-dione 
• 342651-54-1 2-(methylthio)-4-[4-(methylthio)phenyl]-6-(trifluoromethyl) pyrimidine 
• 342651-55-2 2-(methylsulfonyl)-4-[4-(methylsulfonyl)-phenyl]-6-(trifluoromethyl)pyrimidine 
• 459-56-3 4-fluorobenzylic alcohol 

Relevant academic research and scientific papers

Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold

Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental da

USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS

The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.

COMPOSITIONS CONTAINING PYRIMIDINE DERIVATIVES AS INHIBITORS OF COX-2

The invention provides a pharmaceutical composition comprising a compound of formula (I), a potent and selective inhibitor of COX-2, in which the compound is present in solid particles in nanoparticulate form in admixture with one or more pharmaceutically