477743-50-3

Upstream product

• 57384-36-8 6,7-dimethoxy-1-methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 477742-11-3 7,8-dimethoxy-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione 
• 477742-15-7 5-chloro-7,8-dimethoxy-1-methyl-1,3-dihydro-1,4-benzodiazepin-2-one 
• 1679-18-1 4-Chlorophenylboronic acid 

Relevant academic research and scientific papers

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of microto sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4- benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.