477807-74-2

Upstream product

• 142635-27-6 (4R,5S)-4-methyl-5-phenyl-3-<(R)-p-tolylsulfinyl>-2-isoxazolidinone 
• 477807-73-1 2-but-3-ynyl-2-propyl-[1,3]dioxolane 
• 18476-63-6 oct-7-yn-4-one 

Downstream Products

• 7013-58-3 (+)-aspidospermidine 
• 477807-81-1 9a-(2-N,N-bis(t-butoxycarbonylamino)-phenyl)-6a-ethyl-4,5,6,6a,9a,9b-hexahydro-1Hpyrrolo[3,2,1-ij]quinolin-8-en-2,7-dione 
• 477807-80-0 9a-[2-N,N-bis(t-butoxycarbonylamino)-phenyl]-6a-ethyl-octahydro-pyrrolo[3,2,1-ij]quinolin-2,7-dione 
• 477807-79-7 2-[(1S)-1-(2-N,N-bis(t-butoxycarbonyl)amino-phenyl)-3-ethyl-4-oxo-cyclohexene-2-enyl]-N-(3-chloropropyl)-acetamide 
• 477807-78-6 (3R)-3-[2-N,N-bis(t-butoxycarbonylamino)-phenyl]-3-formyl-6-oxo-N-pyrrolidinylnonylamide 
• 477807-77-5 (4R,5R)-4-[2-(N,N-bis-t-butoxycarbonylamino)-phenyl]-4-(3-oxo-hexyl)-5-ptolylsufanyl-dihydro-furan-2-one 
• 477807-84-4 (4R,5R)-4-[2-(N,N-bis-t-butoxycarbonylamino)-phenyl]-4-[2-(2-propyl-[1,3]dioxolan-2-yl)-ethyl]-5-p-tolylsulfanyl-dihydro-furan-2-one 
• 477807-76-4 (4S,5R)-4-[2-(N,N-bis-t-butoxycarbonylamino)-phenyl]-3-dichloro-4-[2-(2-propyl-[1,3]dioxolan-2-yl)-ethyl]-5-p-tolylsulfanyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

Total synthesis of (+)-aspidospermidine: A new strategy for the enantiospecific synthesis of aspidosperma alkaloids

A new strategy was developed for the enantiospecific synthesis of aspidosperma alkaloids. The key steps involve a novel ketene-lactonization reaction of a chiral vinyl sulfoxide to efficiently set up the quaternary carbon center, and a tandem Michael addi