477848-99-0

Usage

Appearance

Yellow solid
The compound has a yellowish color and a solid physical state.

Functional Groups

Malononitrile and sulfonyl
The malononitrile group contributes to its potential applications in organic synthesis and material science, while the sulfonyl group is attached to an indole ring and may contribute to its biological activity.

Indole Ring

Core structure of the compound
The presence of the indole ring may be responsible for the compound's potential anti-cancer and anti-inflammatory properties.

Potential Applications

Medicinal, pharmaceutical, organic synthesis, and material science
The compound has been studied for its possible use in treating cancer and inflammation, as well as its potential in organic synthesis and material science.

Research Status

Further research needed
More studies are required to fully understand the compound's potential uses and properties.

Upstream product

• 50562-79-3 1-(4-tolylsulfonyl)indole-3-carboxaldehyde 
• 109-77-3 malononitrile 
• 487-89-8 Indole-3-carboxaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Catalyst-Free Synthesis of Aminals from Indole-Derived α,α-Dicyanoolefins

We have developed an efficient synthesis of indole fused aminals with nucleophilic imines and indole-derived α,α-dicyanoolefins via N -sulfonyl group transfer. The combination of two privileged frameworks, tetrahydroisoquinoline or tetrahydro-β-carboline

Fe-catalyzed multicomponent reactions: The regioselective alkoxy allylation of activated olefins and its application in sequential Fe catalysis

We present herein a versatile and broadly applicable Fe-catalyzed regioselective alkoxy allylation of activated double bonds. Substituted allylic carbonates are converted into the corresponding σ-enyl Fe complexes by reaction with Bu4N[Fe(CO)s

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics

2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.