47789-93-5

Upstream product

• 108-30-5 succinic acid anhydride 
• 477-47-4 picropodophyllotoxin 
• 518-28-5 podofilox 

Downstream Products

• 1043907-99-8 17-deacetyl-17-O-(4-succinylpodophyllotoxinyl)vindoline 
• 1222083-94-4 podophyllotoxinyl 4-(4-methoxyphenethylamino)-4-oxobutanoate 
• 960214-87-3 C₄₇H₄₅ClN₂O₁₄ 
• 1222083-93-3 (R)-podophyllotoxinyl 4-(2-phenylpropylamino)-4-oxobutanoate 
• 1222083-95-5 podophyllotoxinyl 4-[4-{5-(dimethylamino)naphthalene-1-sulfonamido}benzylamino]-4-oxobutanoate 
• 1222083-97-7 N-{(succinylpodophyllotoxinyl)piperazin-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide 
• 1222083-92-2 (S)-N-{(succinylpodophyllotoxinyl)but-4-yl}-2-(3-benzoylphenyl)propanamide 
• 1222083-90-0 (S)-N-{(succinylpodophyllotoxinyl)but-4-yl}-2-(2-fluorobiphenyl-4-yl)propanamide 
• 1222083-89-7 (S)-N-{(succinylpodophyllotoxinyl)but-4-yl}-2-(4-isobutylphenyl)propanamide 
• 1222083-96-6 N-{(succinylpodophyllotoxinyl)pent-5-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide 
• 960214-84-0 N-{(succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide 
• 960214-89-5 podophyllotoxinyl-N-[2-{1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl}-ethylamino]-4-oxobutanoate 

Relevant academic research and scientific papers

Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity

Nano-prodrug is a nanomedicine developed by the reprecipitation method, which allows nanoparticles to be fabricated by only prodrug molecules without using any nanocarriers. In the present study, we synthesized a heterodimer, composed of hinokitiol and po

Insecticidal activity of twin compounds from podophyllotoxin and cytisine

To explore natural-product-based insecticide candidates, and high value-added application of natural plants in agriculture, a series of twin compounds were prepared from two natural products podophyllotoxin and cytisine, which are isolated from the plants

COMPOUND, NANOPARTICLE THEREOF, AND THERAPEUTIC AGENT FOR CANCER DISEASE

PROBLEM TO BE SOLVED: To provide an anticancer active substance which achieves both high dispersion stability and a high drug-carrying rate. SOLUTION: The invention provides a compound represented by the formula [I] in the figure or a pharmaceutically acc

Comparative study of microtubule inhibitors - Estramustine and natural podophyllotoxin conjugated PAMAM dendrimer on glioma cell proliferation

The synthetic estramustine (EM) and natural podophyllotoxin (PODO) anti-mitotic agents that inhibit tubulin polymerization are known anticancer agents. As low bioavailability limits their anticancer properties, we investigated whether conjugation with PAMAM dendrimer (D) could enhance the activity of D-EM and D-PODO by altering their release pattern. Release kinetics indicated synthesized conjugates to be stable against hydrolytic cleavage and showed sustained release characteristics. However, release of D-EM was slow compared to D-PODO conjugate. Antitumor effect of these conjugates on glioma cells revealed (i) increased cell death and cell cycle arrest (ii) decreased migration and (iii) increased tubulin depolymerization as compared to free drug. Importantly, the effects of natural PODO conjugate on glioma cell survival and migration is more pronounced than D-EM.

Podophyllotoxin analogues active versus Trypanosoma brucei

In an effort to discover novel anti-trypanosomal compounds, a series of podophyllotoxin analogues coupled to non-steroidal anti-inflammatory drugs (NSAIDs) has been synthesized and evaluated for activity versus Trypanosoma brucei and a panel of human cell lines, revealing compounds with low nano-molar potencies. It was discovered that coupling of NSAIDs to podophyllotoxin increased the potencies of both compounds over 1300-fold. The compounds were shown to be cytostatic in nature and seem to act via de-polymerization of tubulin in a manner consistent with the known activities of podophyllotoxin. The potencies against T. brucei correlated directly with Log P values of the compounds, suggesting that the conjugates are acting as hydrophobic tags allowing podophyllotoxin to enter the cell.

Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III

A series of novel hybrid compounds obtained by the attachment of anhydrovinblastine, vinorelbine, and vindoline to thiocolchicine, podophyllotoxin, and baccatin III are described. Two types of diacyl spacers are introduced. The influence of the hybrid compounds on tubulin polymerization is reported. The results highlight the importance of the length of the spacer. Immunofluorescence microscopy and flow cytometry measurements that compound with the best in vitro activity could disrupt microtubule networks in cell and prevent the formation of the proper spindle apparatus, thereby causing cell cycle arrest in the G2/M phase. The newly synthesized compounds were tested in the human lung cancer cell line A549.

Podophyllotoxin derivatives

4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer