477950-02-0

Basic information

• Product Name: 2,4(1H,3H)-Quinolinedione, 3-amino-3-phenyl-
• CAS NO: 477950-02-0
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.272
• Mol File: 477950-02-0.mol

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Quinolinedione, 3-amino-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Quinolinedione, 3-amino-3-phenyl-(477950-02-0)
• EPA Substance Registry System: 2,4(1H,3H)-Quinolinedione, 3-amino-3-phenyl-(477950-02-0)

Safety Data

• Hazardous Substances Data: 477950-02-0(Hazardous Substances Data)

Upstream product

• 144603-32-7 3-chloro-3-phenylquinoline-2,4(1H,3H)-dione 
• 128564-87-4 3-azido-3-phenylquinoline-2,4(1H,3H)-dione 
• 14933-29-0 4-hydroxy-3-phenyl-2(1H)-quinolone 

Downstream Products

• 1030030-84-2 2-bromo-N-(2,4-dioxo-3-phenyl-1,2,3,4-tetrahydroquinolin-3-yl)acetamide 
• 1198770-94-3 1,3a-diphenyl-9b-hydroxy-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one 
• 1636897-34-1 1,3-dihydro-3-nitro-3-phenyl-2H-indol-2-one 
• 28864-76-8 1,1’,3,3’-tetrahydro-3,3’-diphenyl-2H,2’H-3,3’-biindole-2,2’-dione 
• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 
• 1254124-53-2 2,3-dihydro-1-phenyl-3-thioxoimidazo[1,5-c]quinazolin-5(6H)-one 
• 1198770-93-2 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one 
• 1030030-77-3 1-hydroxy-1-phenyl-1H-pyrrolo[3,4-c]quinoline-3,4(2H,5H)-dione 
• 1030030-60-4 (E)-ethyl 2-(3-amino-2-oxo-3-phenyl-2,3-dihydroquinolin-4(1H)-ylidene)acetate 
• 1030030-70-6 3a-phenyl-3,3a-dihydro-2H-pyrrolo[2,3-c]quinoline-2,4(5H)-dione 
• 1030031-04-9 N-(2,4-dioxo-3-phenyl-1,2,3,4-tetrahydroquinolin-3-yl)acetamide 
• 878554-65-5 3-(3-butylureido)-3-phenyl-1H,3H-quinoline-2,4-dione 
• 878554-66-6 3-phenyl-3-(3-phenylureido)-1H,3H-quinoline-2,4-dione 

Relevant articles and documents

Novel heterocyclic dione derivative or pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for protection of brain neural cell containing the same as an active ingredient

The present invention refers to novel heterocyclic gap click dyon derivative acceptable salt, manufacturing method thereof and cranial nerve protecting compound produced by agent comprising a pharmaceutical composition is disclosed with a. gap click dyon , a heterodyne represented by the present invention according to formula 1, provided are a method for anti-convulsive derivatives as well as, if it reaches the set temperature and ischemia-induced cell damage to the ischemia after reperfusion the delay for minimizing the damage on that arise in the brain cell current so as excellent effect for protecting agent comprising a cranial nerve pharmaceutical compositions useful pharmaceutical compositions for protecting compound produced by can be used.

Syntheses of 3-aminoquinoline-2,4(1H,3H)-diones

Reaction of 3-chloro- (2) and 3-bromoquinoline-2,4(1H,3H)-diones (3) with excess of primary alkyl- or arylamines in dimethylformamide provides the corresponding 3-alkyl- or 3-arylamino derivatives (4). Compounds (4) with the primary amino group at the 3 position were best prepared by reaction of 2 with in situ generated ammonia under anhydrous conditions. An alternative approach to the primary amines (4) via reduction of 3-azidoquinoline-2,4(1H,3H)-diones (5) was investigated. The reduction of 5 with zinc in acetic acid gave moderate to good yields of the desired products, while the reaction with triphenylphosphine afforded exclusively 4-hydroxyquinolin-2(1H)-one (1).