139018-14-7

Basic information

• Product Name: 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one
• Synonyms: 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one
• CAS NO: 139018-14-7
• Molecular Weight: 225.247
• Mol File: 139018-14-7.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one(139018-14-7)
• EPA Substance Registry System: 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one(139018-14-7)

Safety Data

• Hazardous Substances Data: 139018-14-7(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 948-65-2 2-phenyl-indole 
• 577-19-5 2-nitrophenyl bromide 
• 52208-62-5 (Z)-2-nitrostilbene 
• 4264-29-3 (E)-2-nitrostilbene 
• 53774-34-8 2-(2-nitrophenyl)-3-phenyloxirane 
• 477950-02-0 3-amino-3-phenylquinoline-2,4(1H,3H)-dione 
• 841-76-9 triphenylaluminium 
• 59-48-3 2-oxoindole 
• 108-90-7 chlorobenzene 
• 3456-79-9 3-phenyloxindole 
• 1415722-80-3 C₃₁H₂₉NO₄ 
• 100-58-3 phenylmagnesium bromide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 3456-79-9 3-phenyloxindole 
• 783324-18-5 4-tert-butyl-N-[5-hydroxy-4-methyl-2-(2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)-phenyl]-benzenesulfonamide 
• 34638-57-8 3-methoxy-3-phenyl-1,3-dihydro-indol-2-one 
• 42773-29-5 3-ethoxy-3-phenylindolin-2-one 
• 112222-86-3 3-phenyl-1-tosylindolin-2-one 
• 114794-99-9 3-ethoxy-1-benzoyl-3-phenyl-indolin-2-one 
• 900811-77-0 3-phenyl-3-hydroxy-1,3-dihydro-indol-2-one 
• 1848-24-4 3-phenyl-3-hydroxy-1,3-dihydro-indol-2-one 
• 1463045-73-9 (±)-3-(1H-indol-3-yl)-3-phenylindolin-2-one 
• 1351708-13-8 (S)-3-amino-3-phenylindolin-2-one 
• 685890-94-2 3-{5-tert-butyl-2-hydroxyphenyl}-3-phenyl-1,3-dihydro-2H-indol-2-one 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 42773-27-3 3-chloro-3-phenyl-1,3-dihydroindol-2-one 

Relevant articles and documents

Indole-based allosteric inhibitors of HIV-1 integrase

Employing a scaffold hopping approach, a series of allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) have been synthesized based on an indole scaffold. These compounds incorporate the key elements utilized in quinoline-based ALLINIs for binding to the IN dimer interface at the principal LEDGF/p75 binding pocket. The most potent of these compounds displayed good activity in the LEDGF/p75 dependent integration assay (IC50?=?4.5?μM) and, as predicted based on the geometry of the five- versus six-membered ring, retained activity against the A128T IN mutant that confers resistance to many quinoline-based ALLINIs.

Synthetic Studies toward 1,2,3,3a,4,8b-Hexahydropyrrolo[3,2-b]indole Core. Unusual Fragmentation with 1,2-Aryl Shift

Base-assisted transformations of 2-(3-oxoindolin-2-yl)acetonitriles were investigated. Unexpectedly, attempted reactions of substrates possessing nonprotected nitrogen atoms were accompanied by unusual extrusions of 2-arylacetonitriles, followed by a 1,2-aryl shift to afford 3-hydroxyindolin-2-ones. On the other hand, the reactions for N-alkyl derivatives of oxoindolines took the expected route by only providing 1,2,3,3a,4,8b-hexahydropyrrolo[3,2-b]indoles.

Electrochemical Umpolung C-H Functionalization of Oxindoles

Herein, we present a general electrochemical method to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxindole fragment behaves as an electrophile. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.