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(6aR)-5,6,6a,7-Tetrahydro-10-methoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,11-diol is a complex organic compound belonging to the class of dibenzoquinoline derivatives. It is characterized by a unique molecular structure, featuring a dibenzoquinoline core with a tetrahydro ring system, a methyl group at the 6-position, and a methoxy group at the 10-position. The compound also has two hydroxyl groups at the 2 and 11 positions, which contribute to its polarity and potential reactivity. This specific arrangement of atoms and functional groups endows the molecule with distinct chemical properties and potential applications in various fields, such as pharmaceuticals or materials science.

478-53-5

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478-53-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 478-53-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 478-53:
(5*4)+(4*7)+(3*8)+(2*5)+(1*3)=85
85 % 10 = 5
So 478-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H19NO3/c1-19-6-5-11-7-12(20)9-13-16(11)14(19)8-10-3-4-15(22-2)18(21)17(10)13/h3-4,7,9,14,20-21H,5-6,8H2,1-2H3

478-53-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Morphothebaine

1.2 Other means of identification

Product number -
Other names morphothebaine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:478-53-5 SDS

478-53-5Relevant academic research and scientific papers

Microwave-promoted acid-catalyzed rearrangement of morphinans - A high-yield synthesis of R(-)-apomorphine

Csutoras,Berenyi,Neumeyer

, p. 866 - 872 (2008)

The microwave-promoted acid-catalyzed rearrangement of morphine (1), codeine (2), and thebaine (3) was investigated. In all cases, a significant improvement in the yields were achieved compared to the traditional techniques. R(-)-Apomorphine (4), which is a clinically important dopamine agonist, was synthesized from morphine (1) in 75% yield. Copyright Taylor & Francis Group, LLC.

Salutaridine and its derivatives as thebaine-equivalents in the synthesis of aporphines

Udvardy, Antal,Sipos, Attila

, p. 2022 - 2030 (2013/10/22)

Here we report the transformation of tetracyclic morphinan salutaridine (1) into 2,3,10,11-tetrasubstituted (R)-aporphines. This method serves as another chemical proof of the previously verified biosynthetic connection with pentacyclic morphinan-6,8-dien

Synthesis and binding studies of 2-arylapomorphines

Sondergaard, Kare,Kristensen, Jesper Langgaard,Palner, Mikael,Gillings, Nie,Knudsen, Gitte Moos,Roth, Bryan L.,Begtrup, Mikael

, p. 4077 - 4081 (2007/10/03)

From codeine, four different 2-aryl substituted apomorphines were synthesised in 6 steps each. Oxidation of codeine with IBX followed by acid catalysed rearrangement gave morphothebaine, which was selectively triflylated at the 2-position and subsequently O-acetylated at the 11-position. The resulting triflate was coupled in a Suzuki-Miyaura type reaction with a series of 4-substituted arylboronic esters which, after deprotection, gave the desired 2-aryl apomorphines. The analogues were tested for affinity towards a range of dopaminergic, serotonergic and adrenergic receptors. 2-(4-Hydroxyphenyl)- apomorphine exhibited high affinity for the dopamine D2 receptor. A putative ligand-receptor interaction was put forward. The Royal Society of Chemistry 2005.

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