478007-80-6

Basic information

• Product Name: Methanol, (phenylphosphinylidene)bis-, diacetate
• CAS NO: 478007-80-6
• Molecular Formula: C12H15O5P
• Molecular Weight: 270.222
• Mol File: 478007-80-6.mol

Chemical Properties

• CAS DataBase Reference: Methanol, (phenylphosphinylidene)bis-, diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methanol, (phenylphosphinylidene)bis-, diacetate(478007-80-6)
• EPA Substance Registry System: Methanol, (phenylphosphinylidene)bis-, diacetate(478007-80-6)

Safety Data

• Hazardous Substances Data: 478007-80-6(Hazardous Substances Data)

Upstream product

• 39118-56-4 bis(hydroxymethyl)phenylphosphine oxide 
• 108-24-7 acetic anhydride 
• 108-05-4 vinyl acetate 

Relevant articles and documents

The first enzymatic desymmetrizations of prochiral phosphine oxides

Prochiral bis(methoxycarbonylmethyl)phenylphosphine oxide was subjected to PLE-mediated hydrolysis to give a chiral monoacetate in 92% yield and 72% e.e. In turn, prochiral bis(hydroxymethyl)phenylphosphine oxide was desymmetrized, using either a lipase-catalyzed acetylation or hydrolysis of the corresponding diacetyl derivative, to give a chiral monoacetate in the yield up to 76% and with e.e.s up to 79%. Absolute configurations of the products were determined by means of chemical correlation.