478014-77-6Relevant academic research and scientific papers
Tetrasubstituted thiuronium salts as multitarget compounds affecting brain NMDA and AMPA receptors
Proshin,Grigor’ev,Tikhonova,Palyulin,Bachurin
, p. 2189 - 2194 (2016/10/03)
Tetrasubstituted N′,N′-dibenzylisothioureas were shown to activate AMPA receptors. A number of structural specificities determining activity of the synthesized compounds against NMDA and AMPA receptors were identified.
Novel isothiourea derivatives as potent neuroprotectors and cognition enhancers: synthesis, biological and physicochemical properties
Perlovich, German L.,Proshin, Alexey N.,Volkova, Tatyana V.,Kurkov, Sergey V.,Grigoriev, Vlaimir V.,Petrova, Ludmila N.,Bachurin, Sergey O.
experimental part, p. 1845 - 1852 (2009/12/31)
Various salts of 3-allyl-1,1-dibenzyl-2-ethyl-isothiourea, 1 (hydrochloride), 2 (hydrobromide), and 3 (hydroiodide), were synthesized. Ca-blocking properties of these salts were studied. Comparative analysis of the potentiating effects of 3 and cyclothiaz
