478077-40-6 Usage
Chemical Structure
A compound containing a piperazine core with a sulfonamide and a pyridinyl group attached to it.
4-Methylphenylsulfonyl Group
A benzene ring with a methyl group and a sulfonyl group attached to it.
3-(Trifluoromethyl)-2-Pyridinyl Group
A pyridine ring with a trifluoromethyl group attached to it.
Potential Applications
Pharmaceutical industry.
Biological Activities
Exhibits a wide range of biological activities, including as antipsychotics, antihistamines, and anxiolytics.
Sulfonamide Group
Often found in drugs as they can act as enzyme inhibitors and have antibacterial and diuretic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 478077-40-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,0,7 and 7 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 478077-40:
(8*4)+(7*7)+(6*8)+(5*0)+(4*7)+(3*7)+(2*4)+(1*0)=186
186 % 10 = 6
So 478077-40-6 is a valid CAS Registry Number.
478077-40-6Relevant academic research and scientific papers
Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)
Sun, Daqing,Wang, Zhulun,Di, Yongmei,Jaen, Juan C.,Labelle, Marc,Ma, Ji,Miao, Shichang,Sudom, Athena,Tang, Liang,Tomooka, Craig S.,Tu, Hua,Ursu, Stefania,Walker, Nigel,Yan, Xuelei,Ye, Qiuping,Powers, Jay P.
scheme or table, p. 3513 - 3516 (2009/04/11)
High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).
