87394-63-6

Usage

Uses

Used in Pharmaceutical Industry:
1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE is used as a synthetic intermediate for the development of new drug candidates due to its ability to enhance the biological activity of resulting compounds.
Used in Agrochemical Industry:
1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE is used as a building block in the synthesis of agrochemicals, contributing to the development of new compounds for agricultural applications.
Used in Organic Chemistry:
1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE is used as a versatile chemical intermediate in the synthesis of various organic compounds, leveraging its unique structural features for diverse applications.

InChI:InChI=1/C10H12F3N3/c11-10(12,13)8-2-1-3-15-9(8)16-6-4-14-5-7-16/h1-3,14H,4-7H2

Upstream product

• 110-85-0 piperazine 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 584-08-7 potassium carbonate 
• 946399-62-8 tert-butyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate 
• 65753-52-8 2-fluoro-3-trifluoromethylpyridine 

Downstream Products

• 548768-70-3 4-[3-(Trifluoromethyl)pyridin-2-yl]-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 1043475-92-8 C₁₉H₂₂F₃N₃O₂S 
• 1043475-85-9 C₁₈H₂₀F₃N₃O₂S 
• 1043475-99-5 C₁₆H₁₅F₄N₃O₂S 
• 1043476-04-5 C₁₇H₁₅F₆N₃O₂S 
• 1043475-80-4 C₁₇H₁₈F₃N₃ 
• 260392-56-1 C₁₇H₁₆F₃N₃O 
• 478077-42-8 C₁₆H₁₅ClF₃N₃O₂S 
• 478077-40-6 C₁₇H₁₈F₃N₃O₂S 
• 478077-41-7 C₁₇H₁₈F₃N₃O₃S 
• 1043476-09-0 C₁₆H₁₅F₃N₄O₄S 
• 259793-04-9 1-[(3,4-dichlorophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine 

Relevant academic research and scientific papers

ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES

The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and in particular as glycosidase inhibitors.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

COMPOUNDS AS TRVP1 BLOCKERS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF

A kind of new compounds, and their pharmaceutically acceptable salts, and hydrates are disclosed. The pharmaceutical composition thereof is also provided. And also are the medical uses of the compounds, pharmaceutically acceptable salts, hydrates and the

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.

Piperazine sulfonamides as potent, selective, and orally available 11β-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme that converts cortisone to cortisol. Evidence suggests that selective inhibition of 11β-HSD1 could treat diabetes and metabolic syndrome. Presented herein are the synthesis, structure-activity relationship, and in vivo evaluation of piperazine sulfonamides as 11β-HSD1 inhibitors. Through modification of our initial lead 5a, we have identified potent and selective 11β-HSD1 inhibitors such as 13q and 13u with good pharmacokinetic properties.

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).

11-BETA HSD1 INHIBITORS

This invention relates to inhibiting 11βHSD1.

1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS

Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.

DIAZA HETEROCYCLIC SULFONAMIDE DERIVATIVES AND THEIR USES

Diaza heterocyclic sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: I where R7, R8, R9, R10, R11, R12, R13, X, Y1, Y2, m, and n are set forth in the description.

Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2- yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist

High throughput screening using the recombinant human TRPV1 receptor was used to identify a series of pyridinylpiperazine ureas (3) as TRPV1 vanilloid receptor ligands. Exploration of the structure-activity relationships by parallel synthesis identified t