Basic information

Product Name: PHA-543613 Dihydrochloride
Synonyms: PHA-543613 Dihydrochloride;N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxaMide Dihydrochloride;PHA 543613E
CAS NO:478148-58-2
Molecular Formula: C15H17N3O2
Molecular Weight: 271.31438
EINECS: N/A
Product Categories: Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals
Mol File: 478148-58-2.mol

Chemical Properties

Melting Point: >300?C
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: N/A
Refractive Index: N/A
Storage Temp.: Refrigerator
Solubility: DMSO, Methanol
CAS DataBase Reference: PHA-543613 Dihydrochloride(CAS DataBase Reference)
NIST Chemistry Reference: PHA-543613 Dihydrochloride(478148-58-2)
EPA Substance Registry System: PHA-543613 Dihydrochloride(478148-58-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 478148-58-2(Hazardous Substances Data)

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SDS
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478148-58-2 Usage

Uses

Used in Pharmaceutical Industry:
PHA-543613 Dihydrochloride is used as a therapeutic agent for cognitive deficits associated with schizophrenia and Alzheimer's disease. It targets the α7 nicotinic acetylcholine receptor, which is a potential therapeutic target for these conditions. PHA-543613 Dihydrochloride has demonstrated activity in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays, indicating its potential effectiveness in treating cognitive impairments.
Used in Research and Development:
PHA-543613 Dihydrochloride is also used as a research tool in the study of the α7 nAChR and its role in cognitive function. It can be employed in various assays to investigate the receptor's function and to develop new therapeutic strategies for cognitive disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 478148-58-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,1,4 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 478148-58:
(8*4)+(7*7)+(6*8)+(5*1)+(4*4)+(3*8)+(2*5)+(1*8)=192
192 % 10 = 2
So 478148-58-2 is a valid CAS Registry Number.

478148-58-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	PHA-543613 Dihydrochloride

1.2 Other means of identification

Product number	-
Other names	N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:478148-58-2 SDS

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