478157-85-6Relevant academic research and scientific papers
Industrial synthesis of 4-chloro, 11β-arylestradiol: How to circumvent a poor diastereoselectivity
Prat, Denis,Benedetti, Francoise,Girard, Gilles Franc,Bouda, Lahlou Nait,Larkin, John,Wehrey, Christian,Lenay, Jacques
, p. 219 - 228 (2004)
An industrial synthesis of 11β-arylestrone derivatives is described, based on the conjugate opening of a mixture of allylic 5(10)-α and -β epoxides by an aryl cuprate generated catalytically, followed by hydrolysis and subsequent aromatisation of the isomeric mixture of arylation products. An original method for selective 4-chlorination of estrone derivatives is also described.
