1823-62-7

Basic information

• Product Name: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE
• Synonyms: [2-(4-BROMO-PHENOXY)-ETHYL]-DIETHYL-AMINE;4-(2-DIETHYLAMINO)ETHOXY-BROMOBENZENE;4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE;4-(2-N,N-DIETHYLAMINOETHOXY)BROMOBENZENE;Ethanamine, 2-(4-bromophenoxy)-N,N-diethyl-
• CAS NO: 1823-62-7
• Molecular Formula: C₁₂H₁₈BrNO
• Molecular Weight: 272.18
• Mol File: 1823-62-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 319.5 °C at 760 mmHg
• Flash Point: 147 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0.000338mmHg at 25°C
• Refractive Index: 1.527
• PKA: 9.54±0.25(Predicted)
• CAS DataBase Reference: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE(1823-62-7)
• EPA Substance Registry System: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE(1823-62-7)

Safety Data

• Hazardous Substances Data: 1823-62-7(Hazardous Substances Data)

Usage

Description

4-[2-N,N-Diethylethoxy]phenyl bromide is a chemical compound that belongs to the class of phenyl bromides. It is a derivative of phenyl bromide, with the addition of a diethylethoxy group at the 2-position of the phenyl ring. 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE is commonly used in organic synthesis and serves as a valuable building block for the preparation of various pharmaceuticals, agrochemicals, and materials. It also has the potential for use as a substrate for the synthesis of novel compounds with potential biological activity. Due to its halogenated nature, it is important to handle and use this compound with caution to avoid hazardous effects.

Uses

Used in Pharmaceutical Industry:
4-[2-N,N-Diethylethoxy]phenyl bromide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-[2-N,N-Diethylethoxy]phenyl bromide is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Material Science:
4-[2-N,N-Diethylethoxy]phenyl bromide is employed as a building block in material science for the development of new materials with specific properties, such as improved stability or reactivity in various applications.
Used in Organic Synthesis:
As a versatile chemical intermediate, 4-[2-N,N-Diethylethoxy]phenyl bromide is used in organic synthesis for the preparation of a wide range of organic compounds, including those with potential biological activity, thus contributing to the discovery of new chemical entities.

InChI:InChI=1/C12H18BrNO/c1-3-14(4-2)9-10-15-12-7-5-11(13)6-8-12/h5-8H,3-4,9-10H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 106-41-2 4-bromo-phenol 
• 7003-65-8 sodium 4-bromophenoxide 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 100-35-6 2-(diethylamino)ethyl chloride 

Downstream Products

• 3704-91-4 1-[4-(2-Diethylamino-ethoxy)-phenyl]-1-(3,4,5-trimethoxy-phenyl)-ethylen 
• 3950-35-4 (Biphenyl-4-yl)-<4-(2-diethylamino-ethoxy)-phenyl>-phenylmethanol 
• 3704-70-9 <4-(2-Diaethylamino-aethoxy)-phenyl>-phenyl-<4-trifluormethyl-phenyl>-methanol 
• 749-86-0 {2-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenoxy]-ethyl}-diethyl-amine 
• 3704-74-3 (4-Chlor-phenyl)-cyclopropyl-[4-(2-diethylamino-ethoxy)-phenyl]-methanol 
• 3704-75-4 [4-(2-Diaethylamino-aethoxy)-phenyl]-(4-methyl-phenyl)-phenaethyl-methanol 
• 2041-71-6 Diethyl-{2-[4-((E)-1,2,3-triphenyl-propenyl)-phenoxy]-ethyl}-amine 
• 2239-35-2 {2-[4-((Z)-1,2-Diphenyl-penta-1,4-dienyl)-phenoxy]-ethyl}-diethyl-amine 
• 2041-70-5 Diethyl-{2-[4-((E)-2-phenyl-1-p-tolyl-propenyl)-phenoxy]-ethyl}-amine 
• 2041-72-7 {2-[4-((Z)-1,2-Diphenyl-pent-1-enyl)-phenoxy]-ethyl}-diethyl-amine 
• 2220-38-4 (Acenaphthen-5-yl)-<4-(2-diethylamino-ethoxy)-phenyl>-phenyl-methanol 
• 3704-71-0 <4-(2-Diethylamino-ethoxy)-phenyl>--methanol 
• 2041-73-8 Diethyl-(2-{4-[(E)-1-(4-methoxy-phenyl)-2,3-diphenyl-propenyl]-phenoxy}-ethyl)-amine 
• 2236-17-1 2-(4-Chloro-phenyl)-1-[4-(2-diethylamino-ethoxy)-phenyl]-1-phenyl-propan-1-ol 

Relevant articles and documents

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS

The invention relates to alkyne compounds of general formula (I), in which groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings as cited in Claim 1. The invention also relates to medicaments containing at least one inventive alkyne. The MCH receptor antagonistic effect renders the inventive medicaments suitable for treating metabolic disorders and/or eating disorders, in particular, obesity, bulimia, anorexia, hyperphagia and diabetes.

Sila-Pharmaca, 34th communication [1]. Sila-analogues of triparanol and ethamoxytriphetol: Synthesis as well as pharmacological and toxicological properties

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