1823-62-7

Usage

Uses

Used in Pharmaceutical Industry:
4-[2-N,N-Diethylethoxy]phenyl bromide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-[2-N,N-Diethylethoxy]phenyl bromide is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Material Science:
4-[2-N,N-Diethylethoxy]phenyl bromide is employed as a building block in material science for the development of new materials with specific properties, such as improved stability or reactivity in various applications.
Used in Organic Synthesis:
As a versatile chemical intermediate, 4-[2-N,N-Diethylethoxy]phenyl bromide is used in organic synthesis for the preparation of a wide range of organic compounds, including those with potential biological activity, thus contributing to the discovery of new chemical entities.

InChI:InChI=1/C12H18BrNO/c1-3-14(4-2)9-10-15-12-7-5-11(13)6-8-12/h5-8H,3-4,9-10H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 106-41-2 4-bromo-phenol 
• 7003-65-8 sodium 4-bromophenoxide 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 100-35-6 2-(diethylamino)ethyl chloride 

Downstream Products

• 3704-91-4 1-[4-(2-Diethylamino-ethoxy)-phenyl]-1-(3,4,5-trimethoxy-phenyl)-ethylen 
• 3704-73-2 1-[4-(2-Diethylamino-ethoxy)-phenyl]-1-(4-fluor-phenyl)-ethanol 
• 100148-67-2 [2-(4-Bromo-phenoxy)-ethyl]-(2-chloro-benzyl)-diethyl-ammonium; iodide 
• 3704-92-5 3-<4-(2-Diaethylamino-aethoxy)-phenyl>-inden 
• 109629-86-9 <4-(2-Diethylaminoethoxy)phenyl>methoxy(4-methoxybenzyl)phenylsilan 
• 73675-53-3 1-phenyl-2-<4-(2-diethylaminoethoxy)phenyl>acetylene 
• 131558-79-7 Diethyl-[2-(4-prop-1-ynyl-phenoxy)-ethyl]-amine 
• 47739-22-0 4-[1-[4-(2-Diethylamino-ethoxy)-phenyl]-1-hydroxy-2-(4-methoxy-phenyl)-butyl]-phenol 
• 10048-83-6 1-<4-(2-Diaethylamino-aethoxy)-phenyl>-2-phenyl-1-hydroxy-1,2,3,4-tetrahydro-naphthalin 
• 1908-03-8 6-Methoxy-1-<4-(2-diaethylamino-aethoxy)-phenyl>-2-phenyl-3,4-dihydro-naphthalin 
• 35271-48-8 trans-1,2-Bis(p-methoxyphenyl)-1-(p-<2-(N,N-diethylamino)-ethoxy>-phenyl)-buten-1 
• 102345-54-0 2-<4-Methoxy-phenyl>-3-<4-(2-diaethylamino-aethoxy)-phenyl>-inden 
• 102345-53-9 3-<4-(2-Diaethylamino-aethoxy)-phenyl>-5-methoxy-2-phenyl-inden 
• 106845-07-2 2-<4-Chlor-phenyl>-3-<4-(2-diaethylamino-aethoxy)-phenyl>-6-methoxy-inden 

Relevant academic research and scientific papers

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Industrial synthesis of 4-chloro, 11β-arylestradiol: How to circumvent a poor diastereoselectivity

An industrial synthesis of 11β-arylestrone derivatives is described, based on the conjugate opening of a mixture of allylic 5(10)-α and -β epoxides by an aryl cuprate generated catalytically, followed by hydrolysis and subsequent aromatisation of the isomeric mixture of arylation products. An original method for selective 4-chlorination of estrone derivatives is also described.

NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS

The invention relates to alkyne compounds of general formula (I), in which groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings as cited in Claim 1. The invention also relates to medicaments containing at least one inventive alkyne. The MCH receptor antagonistic effect renders the inventive medicaments suitable for treating metabolic disorders and/or eating disorders, in particular, obesity, bulimia, anorexia, hyperphagia and diabetes.

Synthesis, characterization, and fluorescence quenching of novel cationic phenyl-substituted poly(p-phenylenevinylene)s

Three new phenyl-substituted poly(p-phenylenevinylene) (Ph-PPV) derivatives with amino-functionalized groups were synthesized through either Gilch reaction for poly{2,5-bis[4′-2-(N,N-diethylamino)ethoxyphenyl]-1,4-phenylenevinylene (P1) or Wittig reaction for poly{2,5-bis(4′-decyloxyphenyl)-1,4-phenylenevinylene-alt-2,5-bis[4′ -2-(N,N-diethylamino)ethoxyphenyl]-1,4-phenylenevinylene} (P2) and poly(2,5-bis{4′-2-[2-(2-methoxyethoxy)ethoxy]ethoxyphenyl}-1,4-phenylenevi nylene-alt-2,5-bis[4′-2-(N,N-diethylamino)ethoxyphenyl]-1,4- phenylenevinylene) (P3). Green light-emitting cationic polymers, poly{2,5-bis(4′-decyloxyphenyl)-1,4-phenylenevinylene-alt-2,5-bis[4′ -2-(N,N,N-triethylammonium)ethoxyphenyl]-1,4-phenylenevinylene} dibromide (P2′) and poly(2,5-bis{4′-2-[2-(2-methoxyethoxy)ethoxy]ethoxyphenyl}-1,4-phenylenevi nylene-alt-2,5-bis[4′-2-(N,N,N-triethylammonium)ethoxyphenyl]-1, 4-phenylenevinylene) dibromide (P3′), were prepared from the neutral polymers P2 and P3, respectively. Water solubility was achieved on P3′ through increase of the hydrophilicity of the side chains. The acid-assistant reversible solubility of P1 makes it promising in preparing light-emitting multilayer devices. On the basis of FT-IR and 1H NMR spectra, it was found that P1 is primarily of trans-vinyl while P2 and P3 are of 80% and 81% cis-vinyl, respectively, which depends on the polymerization method employed. The bulky phenyl substituents successfully impeded the interchain interaction which led to quantum efficiency as films comparable to that of solutions. Quaternization also resulted in more twisted conformation of the polymer main chain which was supported by both blue-shifted absorption and reduced quantum efficiency of P2′ and P3′ in solutions and as films than that of the neutral polymers. The fluorescence of P3′ was efficiently quenched by an anionic quencher Fe(CN)64-, Ksv of which is 3.3 × 106 M-1. However, a modified Stern-Volmer plot showed that 9% of the fluophores could not be accessible to the quencher, which may result from the twisted conformation or intermolecular aggregation.

3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols

The invention relates to novel 1-(4-R1 O-phenyl)-2-(4-R2 -phenyl)-6-R3 -1,2,3,4-tetrahydroquinolines having anti-fertility and hypocholesterolemic activities, to their preparation, and to novel intermediates therefor.

Certain 1,2-diphenyl-1,2,3,4-tetrahydroquinoline compounds

The invention relates to novel 1-(4-R1 O-phenyl)-2-(4-R2 -phenyl)-6-R3 -1,2,3,4-tetrahydroquinolines having antifertility and hypocholesterolemic activities, to their preparation, and to novel intermediates therefor.