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BOC-D-PHE(2-I)-OH, also known as BOC-D-Phenylalanine(2-I)-OH, is a scientific organic chemical compound that is primarily used in chemical research and production. It is an amino acid derivative with the IUPAC name (2S)-2-amino-3-(2-iodo-4,5-dimethoxyphenyl)-2-methylpropanoic acid and the CAS number 19883-10-4. The BOC in its name refers to the BOC-protecting group, which protects the amine group in the amino acid during the elongation step of peptide synthesis. It is typically a white to off-white solid and should be stored in a cool, dry place for optimum longevity.

478183-64-1

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478183-64-1 Usage

Uses

Used in Chemical Research and Production:
BOC-D-PHE(2-I)-OH is used as a chemical compound in chemical research and production for its unique properties and reactivity.
Used in Peptide Synthesis:
BOC-D-PHE(2-I)-OH is used as an amino acid derivative in peptide synthesis, where the BOC-protecting group plays a crucial role in protecting the amine group during the elongation step. This protection allows for the controlled synthesis of peptides with specific sequences and functionalities.
Used in Biochemistry:
BOC-D-PHE(2-I)-OH is used as a research tool in biochemistry to study the properties and interactions of amino acids and peptides, contributing to a better understanding of biological processes and the development of new therapeutic strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 478183-64-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,1,8 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 478183-64:
(8*4)+(7*7)+(6*8)+(5*1)+(4*8)+(3*3)+(2*6)+(1*4)=191
191 % 10 = 1
So 478183-64-1 is a valid CAS Registry Number.

478183-64-1Downstream Products

478183-64-1Relevant academic research and scientific papers

2-[ 18 F]Fluorophenylalanine: Synthesis by Nucleophilic 18 F-Fluorination and Preliminary Biological Evaluation

Modemann, Daniel J.,Zlatopolskiy, Boris D.,Urusova, Elizaveta A.,Zischler, Johannes,Craig, Austin,Ermert, Johannes,Guliyev, Mehrab,Endepols, Heike,Neumaier, Bernd

, p. 664 - 676 (2019)

2-[ 18 F]Fluorophenylalanine (2-[ 18 F]FPhe), a promising PET tracer for imaging of cerebral infarction and tumors, was efficiently prepared from an easily accessible iodonium salt precursor using Cu-mediated radiofluorination under 'low base' or 'minimalist' conditions. Whereas significant racemization was initially observed if the 'minimalist' protocol was applied for radiolabeling, it was completely suppressed by the careful adjustment of 18 F - preprocessing. The initial biological study revealed a higher uptake of 2-[ 18 F]FPhe in different tumor cells in comparison to that of [ 18 F]FET. In contrast to 4-[ 18 F]FPhe, which suffered from rapid defluorination in vivo, 2-[ 18 F]FPhe demonstrated a sufficient in vivo stability. Conclusively, 2-[ 18 F]FPhe is a promising PET probe that is now readily available using Cu-mediated radiofluorination under 'minimalist' or 'low base' conditions. The simplicity of the translation of the proposed procedures to automated synthesis modules allows a broad biological evaluation of 2-[ 18 F]FPhe. Notably, a novel protocol for the preparation of N -Boc protected amino acids from the respective Ni-Schiff base complexes was developed that avoided application of strongly acidic conditions.

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