478258-77-4Relevant academic research and scientific papers
Synthesis and reactivity of 1-substituted 2-fluoro- and 2,2-difluoroaziridines
Verniest, Guido,Colpaert, Filip,Van Hende, Eva,De Kimpe, Norbert
, p. 8569 - 8572 (2008/02/13)
(Chemical Equation Presented) A straightforward synthesis toward 2-fluorinated aziridines was developed via ring closure of β-fluorinated β-chloroamines, which were obtained via reduction of the corresponding α-fluorinated amides by borane. When 1-benzyl-2-fluoroaziridine was treated with methanol, reaction occurred at the 2-position, giving rise to N-benzyl-2,2-dimethoxyethylamine, while in the case of 1-benzyl-2,2- difluoroaziridine the 3-position was attacked, giving rise to N-benzyl-2-methoxyacetamide. These reactions point to the divergent reactive behavior of monofluoro- and difluoroaziridines.
