383-62-0

Basic information

• Product Name: Chlorodifluoroacetic acid ethyl ester
• Synonyms: Ethyl chlorodifluoroacetate 98%;Ethyl 2-chloro-2,2-difluoroacetate;Ethyl chlorodifluoroethanoate;Difluorochloroacetic acid ethyl ester;Ethyl chlorodifluoroacetate, Chlorodifluoroacetic acid ethyl ester;Ethyl 2-chloro-2,2-difluoroethanoate, Chloro(difluoro)acetic acid ethyl ester;Ethyl chloroacetatetwo fluorine;Acetic acid,2-chloro-2,2-difluoro-, ethyl ester
• CAS NO: 383-62-0
• Molecular Formula: C₄H₅ClF₂O₂
• Molecular Weight: 158.53
• EINECS: 206-850-0
• Product Categories: Pharmaceutical Intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;C2 to C5;Carbonyl Compounds;Esters
• Mol File: 383-62-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 96-97.5 °C(lit.)
• Flash Point: 65 °F
• Appearance: clear colorless liquid
• Density: 1.252 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.358(lit.)
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 1761413
• CAS DataBase Reference: Chlorodifluoroacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Chlorodifluoroacetic acid ethyl ester(383-62-0)
• EPA Substance Registry System: Chlorodifluoroacetic acid ethyl ester(383-62-0)

Safety Data

• Hazard Codes: F,C,Xi
• Statements: 11-34-20/21/22
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 383-62-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Chlorodifluoroacetic acid ethyl ester is used as a starting reagent for the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols. Its unique chemical properties make it a valuable component in the creation of various chemical compounds and intermediates.
Used in Pharmaceutical Industry:
Chlorodifluoroacetic acid ethyl ester is used as a key intermediate in the synthesis of certain pharmaceutical compounds. Its ability to undergo specific chemical reactions allows for the development of new drugs and medications.
Used in Research and Development:
In the field of research and development, Chlorodifluoroacetic acid ethyl ester is utilized for studying its chemical properties and potential applications in various industries. Its unique reactivity with other compounds opens up new avenues for scientific exploration and innovation.
Used in Specialty Chemicals:
Chlorodifluoroacetic acid ethyl ester is employed in the production of specialty chemicals, where its specific properties are harnessed to create unique products with tailored characteristics for various applications.

InChI:InChI=1/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 
• 1895-39-2 sodium chlorodifluoroacetate 
• 354-24-5 chlordifluoroacetyl chloride 
• 1717-64-2 1,2-dichloro-1,1,2-trifluoro-2-nitrosooxy-ethane 
• 648-48-6 1.1.2.2-Tetrafluor-2-chlor-aethylnitrit 

Downstream Products

• 721-98-2 chloro-difluoro-acetic acid-((S)-1-methyl-2-phenyl-ethylamide) 
• 721-98-2 chloro-difluoro-acetic acid-((R)-1-methyl-2-phenyl-ethylamide) 
• 6312-18-1 2-chloro-2,2-difluoro-1,1-diphenyl-ethanol 
• 421-05-6 chlorodifluoroacetonitrile 
• 152538-73-3 (2,2,2-Trifluoroethoxy)difluoroacetic acid 
• 141546-96-5 ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)propionate 
• 92207-60-8 ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate 
• 21249-93-4 (2,2,2-trifluoroethyl)benzene 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 173067-08-8 chlorodifluoromethyl p-methoxyphenyl ketone 
• 145299-85-0 chlorodifluoromethyl phenethyl ketone 
• 92207-61-9 ethyl 2,2-difluoro-2-(1-hydroxycyclohexyl)acetate 
• 152123-58-5 ethyl 2,2-difluoro-3-hydroxy-3-phenylbutanoate 
• 134682-44-3 Ethyl 2,2-Difluoro-2-cyclohexylacetate 

Relevant articles and documents

METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS

The invention relates to a three-stage method for producing 4, 4-difluoro-acetyl-acetic acid alkylesters. In a first stage, a reaction of 4-chloro-4, 4-difluoro-acetyl-acetic acid alkylesters with trialkyl-phosphites of formula (III) P(OR1)3 is carried out, wherein R1 is C1-C4 alkyl, the R1 groups can be identical or different for producing alkyl-phosphonic acid esters of formula (IV) which react with amine of formula (V) during a second stage, wherein R2 and R3 are hydrogen or C1-C4 alkyl independent of each other, or jointly CH2-CH2-O-CH2-CH2- for forming enamines of formula (VI), wherein R2 and R3 have already mentioned significance, said enamines being hydrolysed in the presence of an acid during a third stage.

Synthesis, characterisation and mass spectrometric fragmentation of O-(chlorodifluoroacylated) alcohols

An indirect and uncatalysed esterification of chlorodifluoroacetic acid with polyfluoro and hydrocarbon alcohols has been developed. The method which involves the reaction between sodium chlorodifluoroacetate and alcohols in dimethylformamide (DMF) is par

Process for the preparation of alkyl halodifluoroacetates

For the preparation of alkyl halodifluoroacetates, a 1,1-difluorotetrahaloethane is reacted with an alcohol in the presence of air and/or oxygen and a free-radical initiator, such as for example an azo compound, e.g., azobis(isobutyronitrile).

Process for producing carboxylic acid esters from carboxylic acid halides and alcohols

A process for preparing carboxylic esters from carboxylic acid halides or carboxylic anhydrides by reacting one of these starting materials with an alcohol under the catalytic action of "onium" or metal salts of carboxylic acids to obtain high yields of products in anhydrous form in a technically simple manner. The process is especially well suited for preparing 1,1,1-trifluoroethyl trifluoroacetate.