478491-22-4

Upstream product

• 478491-19-9 (4E)(2S)-(4-methoxybenzyloxy)-6-(triphenylmethyloxy)hex-4-en-1-ol 
• 478491-18-8 (2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol 
• 478491-04-2 (3S)-4-(tert-butyldiphenylsilanyloxy)-N-methoxy-(4-methoxybenzyloxy)-N-methylbutyramide 
• 478491-17-7 (2E)(5S)-6-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy)hex-2-enoic acid ethyl ester 
• 478491-05-3 (2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether 
• 478491-02-0 (4E)(2S)-(4-methoxybenzyloxy)-6-(triphenylmethyloxy)hex-4-en-1-al 
• 478491-16-6 (3S)-4-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy) butyraldehyde 
• 334706-31-9 (2S)-2-[(E)-2-iodovinyl]-4-methyl-3,6-dihydro-2H-pyran 

Downstream Products

• 115268-43-4 laulimalide 
• 478490-93-6 (2E,7E)(5S,6S)-6-(tert-butyldimethylsilyloxy)-5-(4-methoxy-benzyloxy)-8-((2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal 
• 464914-19-0 (2E,7E)(5S,6S)-6-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-8-((2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dien-1-ol 

Relevant academic research and scientific papers

A de novo enantioselective total synthesis of (-)-laulimalide

An enantioselective total synthesis of the naturally occurring anticancer agent (-)-laulimalide is described. The synthesis is characterized by extensive use of new reaction methodologies based on catalytic asymmetric acyl halide-aldehyde cyclocondensatio