478491-17-7

Upstream product

• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 478491-16-6 (3S)-4-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy) butyraldehyde 
• 221677-48-1 (3S)-4-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-3-[(4-methoxybenzyl)oxy]butan-1-ol 
• 251571-56-9 [(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-methanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 478491-04-2 (3S)-4-(tert-butyldiphenylsilanyloxy)-N-methoxy-(4-methoxybenzyloxy)-N-methylbutyramide 
• 478491-03-1 (S)-4-(((tert-butyldiphenylsilyl)oxy)methyl)oxetan-2-one 
• 478491-15-5 (3S)-4-(tert-butyldiphenylsilanyloxy)-hydroxy-N-methoxy-N-methylbutyramide 

Downstream Products

• 1190042-35-3 (5S)-5-[(4-methoxybenzyl)oxy-]6-heptenoic acid 
• 1190042-34-2 (1R)-1-propyl-3-butenyl (5S)-5-[(4-methoxybenzyl)oxy-]6-heptenoate 
• 172104-03-9 putaminoxin 
• 478491-22-4 tert-butyl-{(4E)(1S,2S)-2-(4-methoxy-benzyloxy)-1-[(1E)-2-((2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-vinyl]-6-trityloxy-hex-4-enyloxy}dimethylsilane 
• 478491-05-3 (2E)(5S)-6-tert-butyldiphenylsiloxy-(4-methoxybenzyloxy)hex-2-en-triphenylmethylether 
• 478491-08-6 (1E,6E)(3S,4S)-4-(4-methoxybenzyloxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]-8-trityloxyocta-1,6-dien-3-ol 
• 478490-93-6 (2E,7E)(5S,6S)-6-(tert-butyldimethylsilyloxy)-5-(4-methoxy-benzyloxy)-8-((2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal 
• 478491-19-9 (4E)(2S)-(4-methoxybenzyloxy)-6-(triphenylmethyloxy)hex-4-en-1-ol 
• 478491-02-0 (4E)(2S)-(4-methoxybenzyloxy)-6-(triphenylmethyloxy)hex-4-en-1-al 
• 464914-19-0 (2E,7E)(5S,6S)-6-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-8-((2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dien-1-ol 
• 115268-43-4 laulimalide 
• 478491-18-8 (2E)(5S)-6-(tert-butyldiphenylsiloxy)-(4-methoxybenzyloxy)hex-2-en-1-ol 

Relevant academic research and scientific papers

Novel synthesis of stagonolide-F, putaminoxin and aspinolide-A

Novel synthesis of putaminoxin, stagonolide-F and aspinolide-A have been achieved by utilizing (S) and (R)- malic acid. The key feature of the synthetic strategy includes Horner-Wittig olefination, double bond reduction and Steglich esterification. Olefinic acid for putaminoxin and stagonolide-F was prepared from (S)-malic acid whereas olefinic acid for aspinolide-A was prepared from (R)-malic acid and olefinic alcohols for putaminoxin, stagonolide-F and aspinolide-A were prepared by using Brown's asymmetric allylboration.

A de novo enantioselective total synthesis of (-)-laulimalide

An enantioselective total synthesis of the naturally occurring anticancer agent (-)-laulimalide is described. The synthesis is characterized by extensive use of new reaction methodologies based on catalytic asymmetric acyl halide-aldehyde cyclocondensatio