478496-91-2

Upstream product

• 67-56-1 methanol 

Downstream Products

• 478496-92-3 2-[(1E)-3-(2,2-dimethoxyethyl)buta-1,3-dienyl]-5-methoxy-1,3,4-trimethylbenzene 
• 478496-90-1 (4E)-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methylidenepent-4-enal 
• 69877-38-9 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2(E),4(E)-pentadien-1-al 
• 69877-39-0 (2Z,4E)-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methylpenta-2,4-dienal 

Relevant academic research and scientific papers

A new stereoselective synthesis of acitretin (=Soriatane, Neotigason)

A new synthesis of acitretin via a C15 + C5 route is reported. The C15 unit is the key step, involving a procedure that provides the required (all-E)-C15-aldehyde with high stereoselectivity.