478555-82-7

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 803-14-5 ethyl 2-bromo-2-(triphenylphosphoranylidene)acetate 

Downstream Products

• 1600528-40-2 (Z)-1,2-dibromo-3-(4-chlorophenyl)-2-propene 
• 42393-39-5 (Z)-2-bromo-3-(4-chlorophenyl)propenoic acid 

Relevant academic research and scientific papers

Cu/CuxOyNPs architectured COF: a recyclable catalyst for the synthesis of oxazolidinedioneviaatmospheric cyclizative CO2utilization

The present study describes the favourable construction of a crystalline covalent organic framework (COF) with exceptional surface area, tunable pore size and huge CO2capture efficiency to facilitate a novel multicomponent cyclization by introducing CO2into extremely reactive organic skeletons. In the presence of a catalytic Cu/CuxOyNP-loaded COF, several 2-bromo-3-alkylacrylic acids combined with several amine derivatives and CO2(0.1 MPa) are converted to the desired oxazolidinediones in excellent yields (up to 96%) under alkali-free conditions and ambient temperature.

Transition metal-free diastereospecific synthesis of (Z)-2-arylidene-2,3-dihydrobenzo[b][1,4]dioxines by reaction of (Z)-1,2-dibromo-3-aryl-2-propenes with catechols

A transition metal-free, diastereospecific reaction between substituted (Z)-1,2-dibromo-3-phenyl-2-propenes and substituted catechols using Cs2CO3 as a base at 140 °C for 18 h delivers exclusively substituted (Z)-2-arylidene-2,3-dihy

Chemical fixation of carbon dioxide by copper catalyzed multicomponent reactions for oxazolidinedione syntheses

The quest to reduce greenhouse gases has triggered the development of new chemical fixation of carbon dioxide. Given the importance of CO2 based transformation chemistry, we demonstrate the fixation of CO2 for oxazolidinedione synthesis via a novel multicomponent synthesis. In the presence of a catalytic amount of Cu2O, various 2-bromo-3-phenylacrylic acid derivatives reacted with CO2 and amines are transformed to the corresponding oxazolidinedione derivatives in high yields. This journal is

Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones

(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.

A convenient method for the synthesis of (Z)-α-haloacrylates: Lewis base-catalyzed carbonyl olefination using α-halo-C,O-bis(trimethylsilyl)ketene acetals

A highly useful method for the stereoselective synthesis of (Z)-α-haloacrylates from various aldehydes that uses α-halogenated ethyl-C,O-bis(trimethylsilyl)ketene acetals in the presence of a Lewis base catalyst such as acetate salts was established. This

Versatile Transformations of α,β-Dibromoesters and Ketones in Basic Media under Microwave Irradiation

Depending on the reaction medium, α,β-dibromoesters under microwave irradiation may selectively lead to α-bromoalk-enes, to alkenes or to (E)-β-bromostyrenes. The corresponding ketones give selectively the α-bromoketones.

α-hypervalent iodine functionalized phosphonium and arsonium ylides and their tandem reaction as umpolung reagents

α-Hypervalent iodine functionalized phosphonium and arsonium ylides 2 can be used as umpolung ylides to react with nucleophiles to give α-heteroatom substituted ylides 4 in good yields. The nucleophilic substitution - Wittig tandem reaction of 2 can occur smoothly to provide an efficient method for the synthesis of (Z)-α-halo-α,β-unsaturated enoates or enones 6, stereoselectively.