803-14-5

Usage

Uses

Used in Organic Synthesis:
Acetic acid, bromo(triphenylphosphoranylidene)-, ethyl ester is used as a reagent for the synthesis of various organic compounds. Its mild and effective reactivity makes it a valuable component in the creation of a wide range of chemical products.
Used in Chemical Research:
In the field of chemical research, Acetic acid, bromo(triphenylphosphoranylidene)-, ethyl ester is utilized for studying reaction mechanisms and exploring new methods in organic chemistry. Its unique properties allow researchers to gain insights into various chemical processes and develop innovative approaches.
Used in Pharmaceutical Industry:
Acetic acid, bromo(triphenylphosphoranylidene)-, ethyl ester is employed in the pharmaceutical industry for the development of new drugs and the improvement of existing ones. Its versatility in organic synthesis contributes to the discovery of novel therapeutic agents and the enhancement of drug delivery systems.
Used in Material Science:
In material science, Acetic acid, bromo(triphenylphosphoranylidene)-, ethyl ester is used for the synthesis of advanced materials with specific properties. Its application in this field aids in the development of new materials for various applications, such as electronics, energy storage, and nanotechnology.

Upstream product

• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 603-35-0 triphenylphosphine 
• 1530-45-6 (carbethoxymethyl)triphenylphosphonium bromide 

Downstream Products

• 40920-30-7 (E)-2-Bromo-5,5-dichloro-4-phenyl-penta-2,4-dienoic acid ethyl ester 
• 197313-84-1 (2Z,4E)-ethyl 2-bromo-5-phenylpenta-2,4-dienoate 
• 254114-37-9 Bromo-[(3aR,4R,6R,6aR)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-acetic acid ethyl ester 
• 871893-64-0 (Z)/(E)-ethyl 3-(4-methoxyphenyl)-2-bromo-2-propenoate 
• 303727-88-0 (Z)-(4S,5R,6S)-2-Bromo-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-2-enoic acid ethyl ester 
• 552321-92-3 (Z)-4-Benzyloxy-2-bromo-but-2-enoic acid ethyl ester 
• 91348-52-6 (E)-ethyl 3-(4-nitrophenyl)-2-bromo-2-propenoate 
• 91348-52-6 ethyl (Z)-2-bromo-3-(4-nitrophenyl)prop-2-enoate 
• 935871-96-8 (S,2Z,4E)-ethyl 2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienoate 
• 1039341-03-1 C₁₁H₁₀Br₂O₂ 

Relevant academic research and scientific papers

Asymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues

The first asymmetric hydrogenation of α-purine nucleobase-substituted α,β-unsaturated esters, catalyzed by a chiral rhodium (R)-Synphos catalyst, has been developed. A wide range of mono- and disubstituted acrylates were successfully hydrogenated under very mild conditions in high yields with good to excellent enantioselectivities (up to 99% ee). This method provides a convenient approach to the synthesis of a new kind of optically pure acyclic nucleoside and Tenofovir analogues.

α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes

Herein α-bromoacrylic acids have been employed as C1 insertion units to achieve the palladium-catalyzed [4 + 1] annulation of 2-iodobiphenyls, which provides an efficient platform for the construction of diverse dibenzofulvenes. This protocol enables the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It is particularly noteworthy that the method features a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, can be successfully incorporated into the products.

Cu/CuxOyNPs architectured COF: a recyclable catalyst for the synthesis of oxazolidinedioneviaatmospheric cyclizative CO2utilization

The present study describes the favourable construction of a crystalline covalent organic framework (COF) with exceptional surface area, tunable pore size and huge CO2capture efficiency to facilitate a novel multicomponent cyclization by introducing CO2into extremely reactive organic skeletons. In the presence of a catalytic Cu/CuxOyNP-loaded COF, several 2-bromo-3-alkylacrylic acids combined with several amine derivatives and CO2(0.1 MPa) are converted to the desired oxazolidinediones in excellent yields (up to 96%) under alkali-free conditions and ambient temperature.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.

Titanocene(III) chloride mediated radical induced addition-elimination route to the synthesis of racemic and optically active trisubstituted tetrahydrofurans: Formal synthesis of magnofargesin and 7’-epimagnofargesin

Titanocene(III) Chloride mediated radical induced synthesis of 4-benzylidene substituted tetrahydrofuran, a typical lignan skeleton, has been accomplished in good yield through addition-elimination route in racemic as well as in optically active forms. The method has been applied to the synthesis of furano lignans, magnofargesin (1) and 7’-epimagnofargesin (2) in optically active forms.

Chemical fixation of carbon dioxide by copper catalyzed multicomponent reactions for oxazolidinedione syntheses

The quest to reduce greenhouse gases has triggered the development of new chemical fixation of carbon dioxide. Given the importance of CO2 based transformation chemistry, we demonstrate the fixation of CO2 for oxazolidinedione synthesis via a novel multicomponent synthesis. In the presence of a catalytic amount of Cu2O, various 2-bromo-3-phenylacrylic acid derivatives reacted with CO2 and amines are transformed to the corresponding oxazolidinedione derivatives in high yields. This journal is

Sequential asymmetric catalysis in Michael-Michael-Michael-aldol reactions: Merging organocatalysis with photoredox catalysis in a one-pot enantioselective synthesis of highly functionalized decalines bearing a quaternary carbon stereocenter

An expedited method has been developed for the enantioselective synthesis of highly functionalized decaline systems containing seven contiguous stereogenic centers with high enantioselectivities (>99% ee). The one-pot methodology comprises a cascade of organocatalytic double Michael-photocatalyzed Michael-aldol reactions of ethyl 2-bromo-6-formylhex-2-enoate, β-alkyl-α,β-unsaturated aldehydes, and α-alkyl-α, β-unsaturated aldehydes. The structure and absolute configuration of an appropriate product were confirmed by X-ray analysis.

Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones

(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.

Nanochannel array within a multilayered network of a planarized dehydro[24]annulene

Dehydro[24]annulene 1c adopts an unusual planarized conformation in the crystal. A multilayered stack of hydrogen-bonded grids delineates tightly packed nanotubular channels. The related macrocycles 1a and 1b, on the other hand, have the expected puckered

A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters

(Chemical Equation Presented) A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or vinyl tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation